Effect of memantine on resting state default mode network activity in Alzheimer's disease.

Memantine is an approved symptomatic treatment for moderate to severe Alzheimer s disease that reduces the excitotoxic effects of hyperactive glutamatergic transmission However the exact mechanism of the effect of memantine in Alzheimer s disease patients is poorly understood Importantly the default mode network DMN which plays a key role in attention is hypoactive in Alzheimer s disease and is under glutamatergic control