Heart failure disease management program, its contribution to established pharmacotherapy and long-term prognosis in real clinical practice - retrospective data analysis.

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BACKGROUND AND AIMS The prognosis of patients with heart failure HF is still generally unfavorable HF with reduced ejection fraction HFrEF patients reach target medication doses in very low percentages in daily clinical practice HF disease management programs DMP including nurse and telemedicine support that facilitate achieving target medication doses may improve the unfavorable prognosis METHODS We retrospectively analyzed the data of 738 patients with HFrEF who were followed in a single HF center during the years 1975 2011 for 6 4 median years DMP nurse and telemedicine support is established at this center RESULTS The group achieved left ventricle LV recovery after the HF treatment The median LV ejection fraction improved from 25 0 at baseline to 50 0 at the time of the latest data collection The proportion of NYHA II III and IV classes decreased from 27 6 30 2 and 29 7 to 26 6 7 2 and 0 1 respectively while the proportion of NYHA class I increased from 12 5 to 66 1 Median NT proBNP decreased from 975 0 to 324 0 pg mL The survival of the patient group was favorable 79 7 survived 18 1 years after diagnosis of HF A high percentage of the patients received recommended target or higher than target doses of angiotensin converting enzyme inhibitors 82 0 and beta blockers 78 1 CONCLUSION The established pharmacotherapy resulted from an effective DMP and this contributed to the favorable prognosis
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