A high-throughput pipeline for designing microarray-based pathogen diagnostic assays.
No Thumbnail Available
Date
2008-04-30
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
We present a methodology for high throughput design of oligonucleotide fingerprints for microarray based pathogen diagnostic assays The oligonucleotide fingerprints or DNA microarray probes are designed for identifying target organisms in environmental or clinical samples The design process is implemented in a high performance computing software pipeline that incorporates major algorithmic improvements over a previous version to both reduce computation time and improve specificity assessment