Hepatopathies in children and adolescents with type 1 diabetes.

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dc.contributor.authorAydın, Firdevs
dc.contributor.authorGerenli, Nelgin
dc.contributor.authorDursun, Fatma
dc.contributor.authorAtasoy, Tülay Öztürk
dc.contributor.authorKalın, Sevinç
dc.contributor.authorKırmızıbekmez, Heves
dc.date.accessioned2020-06-08T14:41:19Z
dc.date.available2020-06-08T14:41:19Z
dc.date.issued0000-00-00
dc.description.abstractBackground Diabetes and hepatosteatosis are dramatically increasing in childhood Non alcoholic fatty liver disease NAFLD is defined as a common disorder in adulthood especially with type 2 diabetes and metabolic syndrome while very few studies are available on liver health in children with type 1 diabetes Patients and methods One hundred and ten 52 males and 58 females patients with type 1 diabetes aged between 8 and 18 years were examined The lipid profile liver enzymes and hepatobiliary ultrasound findings of patients were investigated in terms of hepatopathies Patients diagnosed with fatty liver were evaluated by pediatric gastroenterology specialists for the differential diagnosis and exclusion of other etiologies The relationships between hepatopathy and age pubertal status the duration of diabetes and glycemic control were evaluated Results Hepatopathy was found in 17 15 5 patients The levels of alanine aminotransferase ALT and aspartate aminotransferase AST were normal and did not correlate with the ultrasonography USG findings Hyperechogenicity detected by USG whether it is true fat or glycogen hepatopathy was found to be associated with poor glycemic control independently of age puberty status and the duration of diabetes Conclusions This study contributes to the literature in terms of the relationship between liver health and glycemic control in pediatric type 1 diabetes Hepatopathies were releated with poor glycemic control independently of the duration of diabetes This suggested that liver disorders should be considered as one of the subacute complications of diabetes It was concluded that routine screening for comorbidities and complications in type 1 diabetes should also include hepatobiliary USG as liver enzymes alone are inadequate for detecting hepatopathies
dc.identifier.urihttp://dx.doi.org/10.1515/jpem-2018-0255
dc.identifier.urihttps://lib.digitalsquare.io/handle/123456789/65020
dc.relation.uriJournal of pediatric endocrinology And metabolism : JPEM
dc.titleHepatopathies in children and adolescents with type 1 diabetes.en
dcterms.abstractBackground Diabetes and hepatosteatosis are dramatically increasing in childhood Non alcoholic fatty liver disease NAFLD is defined as a common disorder in adulthood especially with type 2 diabetes and metabolic syndrome while very few studies are available on liver health in children with type 1 diabetes Patients and methods One hundred and ten 52 males and 58 females patients with type 1 diabetes aged between 8 and 18 years were examined The lipid profile liver enzymes and hepatobiliary ultrasound findings of patients were investigated in terms of hepatopathies Patients diagnosed with fatty liver were evaluated by pediatric gastroenterology specialists for the differential diagnosis and exclusion of other etiologies The relationships between hepatopathy and age pubertal status the duration of diabetes and glycemic control were evaluated Results Hepatopathy was found in 17 15 5 patients The levels of alanine aminotransferase ALT and aspartate aminotransferase AST were normal and did not correlate with the ultrasonography USG findings Hyperechogenicity detected by USG whether it is true fat or glycogen hepatopathy was found to be associated with poor glycemic control independently of age puberty status and the duration of diabetes Conclusions This study contributes to the literature in terms of the relationship between liver health and glycemic control in pediatric type 1 diabetes Hepatopathies were releated with poor glycemic control independently of the duration of diabetes This suggested that liver disorders should be considered as one of the subacute complications of diabetes It was concluded that routine screening for comorbidities and complications in type 1 diabetes should also include hepatobiliary USG as liver enzymes alone are inadequate for detecting hepatopathies
dcterms.contributorAydın, Firdevs
dcterms.contributorGerenli, Nelgin
dcterms.contributorDursun, Fatma
dcterms.contributorAtasoy, Tülay Öztürk
dcterms.contributorKalın, Sevinç
dcterms.contributorKırmızıbekmez, Heves
dcterms.identifierhttp://dx.doi.org/10.1515/jpem-2018-0255
dcterms.relationJournal of pediatric endocrinology And metabolism : JPEM
dcterms.titleHepatopathies in children and adolescents with type 1 diabetes.en
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