Nitric oxide level in the nasal and sinus mucosa after exposure to electromagnetic field.
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Date
2005-05-11
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Abstract
OBJECTIVE The purpose of this study was to examine the changes in nitric oxide NO level in the nasal and paranasal sinus mucosa after exposure radiofrequency electromagnetic fields EMF STUDY DESIGN AND SETTING Thirty male Sprague Dawley rats were randomly grouped as follows EMF group group I n 10 EMF group in which melatonin received group II n 10 and the control sham operated group group III n 10 Groups I and II were exposed to a 900 MHz Oral melatonin was given in group II Control rats group III were also placed in the tube as the exposure groups but without exposure to EMF At the end of 2 weeks the rats were sacrificed and the nasal and paranasal sinus mucosa dissected NO was measured in nasal and paranasal mucosa RESULTS The nasal and paranasal sinus mucosa NO levels of group I were significantly higher than those of the control group group III P Under 0 05 However there was no statistically significant difference between group II and the control group group III regarding NO output P 0 05 CONCLUSION Exposure to EMF released by mobile phones 900 MHz increase NO levels in the sinus and nasal mucosa SIGNIFICANCE Increased NO levels may act as a defense mechanism and presumably related to tissue damage In addition melatonin may have beneficial effect to prevent these changes in the mucosa