Pituitary metastases from the oncocytic variant of follicular thyroid carcinoma: a case report and diagnostic dilemmas.

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dc.contributor.authorMatyja, Ewa
dc.contributor.authorZieliński, Grzegorz
dc.contributor.authorWitek, Przemysław
dc.contributor.authorKamiński, Grzegorz
dc.contributor.authorGrajkowska, Wiesława
dc.contributor.authorMaksymowicz, Maria
dc.date.accessioned2020-02-06T18:22:49Z
dc.date.available2020-02-06T18:22:49Z
dc.date.issued2013-10-11
dc.description.abstractMetastases to the pituitary gland and sella turcica are uncommon The distinction between primary and secondary metastatic pituitary tumours is challenging as carcinomas from distant sites might closely resemble both clinically and histopathologically non functional adenomas or primary pituitary carcinomas Among metastases to pituitary gland ones from thyroid carcinoma are extremely rare We present a unique case of a 53 year old male patient with a past history of thyroid carcinoma who underwent repeated surgeries over a period of 7 years for a sellar parasellar mass with paranasal sinus involvement Morphologically the tumour was composed of solid sheaths of monomorphic cells exhibiting oncocytic features In electron microscope images the cytoplasm of tumour cells was filled with numerous mitochondria The tumour was negative for pituitary hormones but exhibited immunoreactivity for cytokeratin AE1 AE3 thyroglobulin and thyroid transcription factor 1 TTF 1 Based on the clinical data and immunophenotypic profile the tumour was finally diagnosed as an oncocytic variant of follicular thyroid carcinoma To our knowledge this is probably the first report of such peculiar histopathological variant of follicular thyroid carcinoma metastasizing to the pituitary gland The diagnostic dilemmas considering oncocytic features of the presented case are discussed
dc.identifier.urihttp://dx.doi.org/Not available
dc.identifier.urihttps://lib.digitalsquare.io/xmlui/handle/123456789/6398
dc.relation.uriFolia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences
dc.titlePituitary metastases from the oncocytic variant of follicular thyroid carcinoma: a case report and diagnostic dilemmas.en
dcterms.abstractMetastases to the pituitary gland and sella turcica are uncommon The distinction between primary and secondary metastatic pituitary tumours is challenging as carcinomas from distant sites might closely resemble both clinically and histopathologically non functional adenomas or primary pituitary carcinomas Among metastases to pituitary gland ones from thyroid carcinoma are extremely rare We present a unique case of a 53 year old male patient with a past history of thyroid carcinoma who underwent repeated surgeries over a period of 7 years for a sellar parasellar mass with paranasal sinus involvement Morphologically the tumour was composed of solid sheaths of monomorphic cells exhibiting oncocytic features In electron microscope images the cytoplasm of tumour cells was filled with numerous mitochondria The tumour was negative for pituitary hormones but exhibited immunoreactivity for cytokeratin AE1 AE3 thyroglobulin and thyroid transcription factor 1 TTF 1 Based on the clinical data and immunophenotypic profile the tumour was finally diagnosed as an oncocytic variant of follicular thyroid carcinoma To our knowledge this is probably the first report of such peculiar histopathological variant of follicular thyroid carcinoma metastasizing to the pituitary gland The diagnostic dilemmas considering oncocytic features of the presented case are discussed
dcterms.contributorMatyja, Ewa
dcterms.contributorZieliński, Grzegorz
dcterms.contributorWitek, Przemysław
dcterms.contributorKamiński, Grzegorz
dcterms.contributorGrajkowska, Wiesława
dcterms.contributorMaksymowicz, Maria
dcterms.identifierhttp://dx.doi.org/Not available
dcterms.relationFolia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences
dcterms.titlePituitary metastases from the oncocytic variant of follicular thyroid carcinoma: a case report and diagnostic dilemmas.en
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