Psychotherapy and Genetic Neuroscience: An Emerging Dialog.

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dc.contributor.authorJiménez, Juan P
dc.contributor.authorBotto, Alberto
dc.contributor.authorHerrera, Luisa
dc.contributor.authorLeighton, Caroline
dc.contributor.authorRossi, José L
dc.contributor.authorQuevedo, Yamil
dc.contributor.authorSilva, Jaime R
dc.contributor.authorMartínez, Felipe
dc.contributor.authorAssar, Rodrigo
dc.contributor.authorSalazar, Luis A
dc.contributor.authorOrtiz, Manuel
dc.contributor.authorRíos, Ulises
dc.contributor.authorBarros, Paulina
dc.contributor.authorJaramillo, Karina
dc.contributor.authorLuyten, Patrick
dc.date.accessioned2020-06-08T14:17:26Z
dc.date.available2020-06-08T14:17:26Z
dc.date.issued0000-00-00
dc.description.abstractRecent research in psychiatric genetics has led to a move away from simple diathesis stress models to more complex models of psychopathology incorporating a focus on gene environment interactions and epigenetics Our increased understanding of the way biology encodes the impact of life events on organisms has also generated more sophisticated theoretical models concerning the molecular processes at the interface between nature and nurture There is also increasing consensus that psychotherapy entails a specific type of learning in the context of an emotional relationship i e the therapeutic relationship that may also lead to epigenetic modifications across different therapeutic treatment modalities This paper provides a systematic review of this emerging body of research It is concluded that although the evidence is still limited at this stage extant research does indeed suggest that psychotherapy may be associated with epigenetic changes Furthermore it is argued that epigenetic studies may play a key role in the identification of biomarkers implicated in vulnerability for psychopathology and thus may improve diagnosis and open up future research opportunities regarding the mechanism of action of psychotropic drugs as well as psychotherapy We review evidence suggesting there may be important individual differences in susceptibility to environmental input including psychotherapy In addition given that there is increasing evidence for the transgenerational transmission of epigenetic modifications in animals and humans exposed to trauma and adversity epigenetic changes produced by psychotherapy may also potentially be passed on to the next generation which opens up new perspective for prevention science We conclude this paper stressing the limitations of current research and by proposing a set of recommendations for future research in this area
dc.identifier.urihttp://dx.doi.org/10.3389/fgene.2018.00257
dc.identifier.urihttps://lib.digitalsquare.io/handle/123456789/63380
dc.relation.uriFrontiers in genetics
dc.titlePsychotherapy and Genetic Neuroscience: An Emerging Dialog.en
dcterms.abstractRecent research in psychiatric genetics has led to a move away from simple diathesis stress models to more complex models of psychopathology incorporating a focus on gene environment interactions and epigenetics Our increased understanding of the way biology encodes the impact of life events on organisms has also generated more sophisticated theoretical models concerning the molecular processes at the interface between nature and nurture There is also increasing consensus that psychotherapy entails a specific type of learning in the context of an emotional relationship i e the therapeutic relationship that may also lead to epigenetic modifications across different therapeutic treatment modalities This paper provides a systematic review of this emerging body of research It is concluded that although the evidence is still limited at this stage extant research does indeed suggest that psychotherapy may be associated with epigenetic changes Furthermore it is argued that epigenetic studies may play a key role in the identification of biomarkers implicated in vulnerability for psychopathology and thus may improve diagnosis and open up future research opportunities regarding the mechanism of action of psychotropic drugs as well as psychotherapy We review evidence suggesting there may be important individual differences in susceptibility to environmental input including psychotherapy In addition given that there is increasing evidence for the transgenerational transmission of epigenetic modifications in animals and humans exposed to trauma and adversity epigenetic changes produced by psychotherapy may also potentially be passed on to the next generation which opens up new perspective for prevention science We conclude this paper stressing the limitations of current research and by proposing a set of recommendations for future research in this area
dcterms.contributorJiménez, Juan P
dcterms.contributorBotto, Alberto
dcterms.contributorHerrera, Luisa
dcterms.contributorLeighton, Caroline
dcterms.contributorRossi, José L
dcterms.contributorQuevedo, Yamil
dcterms.contributorSilva, Jaime R
dcterms.contributorMartínez, Felipe
dcterms.contributorAssar, Rodrigo
dcterms.contributorSalazar, Luis A
dcterms.contributorOrtiz, Manuel
dcterms.contributorRíos, Ulises
dcterms.contributorBarros, Paulina
dcterms.contributorJaramillo, Karina
dcterms.contributorLuyten, Patrick
dcterms.identifierhttp://dx.doi.org/10.3389/fgene.2018.00257
dcterms.relationFrontiers in genetics
dcterms.titlePsychotherapy and Genetic Neuroscience: An Emerging Dialog.en
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