Identification of paroxysmal atrial fibrillation subtypes in over 13,000 individuals.

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dc.contributor.authorWineinger, Nathan E
dc.contributor.authorBarrett, Paddy M
dc.contributor.authorZhang, Yunyue
dc.contributor.authorIrfanullah, Ikram
dc.contributor.authorMuse, Evan D
dc.contributor.authorSteinhubl, Steven R
dc.contributor.authorTopol, Eric J
dc.date.accessioned2020-06-08T14:18:27Z
dc.date.available2020-06-08T14:18:27Z
dc.date.issued0000-00-00
dc.description.abstractBACKGROUND Paroxysmal atrial fibrillation PAF is broadly defined despite high variability in the occurrence and duration of PAF episodes OBJECTIVE We aimed to identify rhythm patterns in a large cohort of individuals with PAF who wore an ambulatory single lead ECG patch sensor as part of standard clinical care METHODS We performed a retrospective analysis of longitudinal rhythm data obtained from 13 293 individuals with PAF RESULTS In this study 7 934 men and 5 359 women with PAF wore an ambulatory single lead ECG patch sensor for 11 4 days on average experiencing 1 041 504 PAF episodes The median daily rate of PAF was 1 21 episodes per day IQR 0 31 4 99 and the median maximum duration per individual was 7 5 hours IQR 2 4 18 6 hours There was an inverse relationship between the duration of PAF episodes and the frequency in which they occurred which became pronounced at moderate and high overall burden of AF This produced a spectrum of PAF flanked by two distinct subtypes of the disease the staccato subtype characterized by many short AF episodes and the legato subtype characterized by fewer longer episodes Longer but less frequent episodes became more common with increasing age Only 49 4 of individuals experienced an episode in the first 24 hours of monitoring increasing to 89 7 after 1 week of monitoring CONCLUSIONS We identified subtypes of the disease that we labeled staccato and legato Although further study is required these subtypes may result from differing elements of pathophysiology and disease progression and may confer differing stroke risks
dc.identifier.urihttp://dx.doi.org/10.1016/j.hrthm.2018.08.012
dc.identifier.urihttps://lib.digitalsquare.io/handle/123456789/63481
dc.relation.uriHeart rhythm
dc.titleIdentification of paroxysmal atrial fibrillation subtypes in over 13,000 individuals.en
dcterms.abstractBACKGROUND Paroxysmal atrial fibrillation PAF is broadly defined despite high variability in the occurrence and duration of PAF episodes OBJECTIVE We aimed to identify rhythm patterns in a large cohort of individuals with PAF who wore an ambulatory single lead ECG patch sensor as part of standard clinical care METHODS We performed a retrospective analysis of longitudinal rhythm data obtained from 13 293 individuals with PAF RESULTS In this study 7 934 men and 5 359 women with PAF wore an ambulatory single lead ECG patch sensor for 11 4 days on average experiencing 1 041 504 PAF episodes The median daily rate of PAF was 1 21 episodes per day IQR 0 31 4 99 and the median maximum duration per individual was 7 5 hours IQR 2 4 18 6 hours There was an inverse relationship between the duration of PAF episodes and the frequency in which they occurred which became pronounced at moderate and high overall burden of AF This produced a spectrum of PAF flanked by two distinct subtypes of the disease the staccato subtype characterized by many short AF episodes and the legato subtype characterized by fewer longer episodes Longer but less frequent episodes became more common with increasing age Only 49 4 of individuals experienced an episode in the first 24 hours of monitoring increasing to 89 7 after 1 week of monitoring CONCLUSIONS We identified subtypes of the disease that we labeled staccato and legato Although further study is required these subtypes may result from differing elements of pathophysiology and disease progression and may confer differing stroke risks
dcterms.contributorWineinger, Nathan E
dcterms.contributorBarrett, Paddy M
dcterms.contributorZhang, Yunyue
dcterms.contributorIrfanullah, Ikram
dcterms.contributorMuse, Evan D
dcterms.contributorSteinhubl, Steven R
dcterms.contributorTopol, Eric J
dcterms.identifierhttp://dx.doi.org/10.1016/j.hrthm.2018.08.012
dcterms.relationHeart rhythm
dcterms.titleIdentification of paroxysmal atrial fibrillation subtypes in over 13,000 individuals.en
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