Differentiation of benign and malignant breast lesions: a comparison between automatically generated breast volume scans and handheld ultrasound examinations.
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2012-10-03
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Abstract
OBJECTIVE To assess the diagnostic value of automated breast volume scanning ABVS or conventional handheld ultrasonography HHUS for the differentiation of benign and malignant breast lesions MATERIALS AND METHODS The study prospectively evaluated 239 lesions in 213 women who were scheduled for open biopsy The patients underwent ABVS and conventional HHUS The sensitivity specificity accuracy false positive rate false negative rate and positive and negative predictive values for HHUS and ABVS images were calculated using histopathological examination as the gold standard Additionally diagnostic accuracy was further evaluated according to the size of the masses RESULTS Among the 239 breast lesions studied pathology revealed 85 35 6 malignant lesions and 154 64 4 benign lesions ABVS was similar to HHUS in terms of sensitivity 95 3 vs 90 6 specificity 80 5 vs 82 5 accuracy 85 8 vs 85 3 positive predictive value 73 0 vs 74 0 and negative predictive value 93 3 vs 94 1 The area under the receiver operating characteristic ROC curve which is used to estimate the accuracy of the methods demonstrated only minor differences between HHUS and ABVS 0 928 and 0 948 respectively CONCLUSIONS The diagnostic accuracy of HHUS and ABVS in differentiating benign from malignant breast lesions is almost identical However ABVS can offer new diagnostic information ABVS may help to distinguish between real lesions and inhomogeneous areas find small lesions and demonstrate the presence of intraductal lesions This technique is feasible for clinical applications and is a promising new technique in breast imaging