White matter lesions in the elderly: pathophysiological hypothesis on the effect on brain plasticity and reserve.

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dc.contributor.authorGalluzzi, Samantha
dc.contributor.authorLanni, Cristina
dc.contributor.authorPantoni, Leonardo
dc.contributor.authorFilippi, Massimo
dc.contributor.authorFrisoni, Giovanni B
dc.date.accessioned2020-02-10T17:16:23Z
dc.date.available2020-02-10T17:16:23Z
dc.date.issued2008-09-01
dc.description.abstractThe effect of white matter lesions WMLs on the brain of elderly individuals is unclear Most debate has focused on the clinical effect of WMLs on cognitive impairment Large cross sectional and longitudinal clinic and population based studies suggest that the effect of WMLs on global cognitive performance is relatively small only individuals with the most severe degrees of WMLs having clinically relevant effects Here we review recent data suggesting that WMLs might affect brain function through impairment of brain plasticity and reserve The clinical effect consists in inability of the brain to respond to interventions such as psychotropic drug medications or rehabilitative interventions
dc.identifier.urihttp://dx.doi.org/10.1016/j.jns.2008.06.023
dc.identifier.urihttps://lib.digitalsquare.io/xmlui/handle/123456789/24974
dc.relation.uriJournal of the neurological sciences
dc.titleWhite matter lesions in the elderly: pathophysiological hypothesis on the effect on brain plasticity and reserve.en
dcterms.abstractThe effect of white matter lesions WMLs on the brain of elderly individuals is unclear Most debate has focused on the clinical effect of WMLs on cognitive impairment Large cross sectional and longitudinal clinic and population based studies suggest that the effect of WMLs on global cognitive performance is relatively small only individuals with the most severe degrees of WMLs having clinically relevant effects Here we review recent data suggesting that WMLs might affect brain function through impairment of brain plasticity and reserve The clinical effect consists in inability of the brain to respond to interventions such as psychotropic drug medications or rehabilitative interventions
dcterms.contributorGalluzzi, Samantha
dcterms.contributorLanni, Cristina
dcterms.contributorPantoni, Leonardo
dcterms.contributorFilippi, Massimo
dcterms.contributorFrisoni, Giovanni B
dcterms.identifierhttp://dx.doi.org/10.1016/j.jns.2008.06.023
dcterms.relationJournal of the neurological sciences
dcterms.titleWhite matter lesions in the elderly: pathophysiological hypothesis on the effect on brain plasticity and reserve.en
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