Subsequent reproductive outcome in couples with repeated pregnancy loss.
No Thumbnail Available
Date
1984-02-14
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
While the role of cytogenetic study in couples with repeated pregnancy loss is well established little information is available for counseling these couples concerning future reproductive outcome Couples evaluated by chromosome analysis for recurrent abortion between 1972 and 1979 were contacted by phone in 1981 Of those studied cytogenetically 195 couples 50 1 could be located and information concerning outcome of subsequent pregnancies were obtained Couples 91 with two consecutive pregnancy losses at the time of initial investigation had a 31 3 subsequent abortion rate but most 68 had at least one liveborn child The rate of infertility following evaluation was slightly increased 18 7 but that of prematurity 11 2 and congenital anomalies 2 5 was not In contrast couples with greater than or equal to 3 consecutive losses 84 experienced abortion in 45 7 of subsequent pregnancies and only 54 8 of them eventually had a liveborn child Again the rate of infertility was increased 26 2 but that of prematurity 10 and congenital defects 3 2 was not Nine couples in which one individual was found to have a chromosome abnormality two inversions and seven translocations were considered separately Of these seven couples had nine liveborn offspring Amniocentesis was performed in eight cases with karyotypes showing a balanced translocation identical to that of the parent in 2 All children were phenotypically normal