From 2014-2020. MEASURE Evaluation supported more than 20 countries in implementing programs to improve health information systems. This included programs to allow different systems to exchange data (interoperability), training staff in data analysis, and improving methods to validate data. What we learned in this work provides a foundation for documenting successful models for strengthening health information systems. In the 11 countries in which USAID investment were highest, MEASURE Evaluation documented the project’s interventions and mapped them to the Health Information Systems Strengthening Model (HISSM).