Browsing by Author "Zetterberg, Henrik"
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- ItemExposure to wireless phone emissions and serum beta-trace protein.(2010-07-02) Hardell, Lennart; Söderqvist, Fredrik; Carlberg, Michael; Zetterberg, Henrik; Mild, Kjell HanssonThe lipocalin type of prostaglandin D synthase or beta trace protein is synthesized in the choroid plexus lepto meninges and oligodendrocytes of the central nervous system and is secreted into the cerebrospinal fluid beta trace protein is the key enzyme in the synthesis of prostaglandin D2 an endogenous sleep promoting neurohormone in the brain Electromagnetic fields EMF in the radio frequency RF range have in some studies been associated with disturbed sleep We studied the concentration of beta trace protein in blood in relation to emissions from wireless phones This study included 62 persons aged 18 30 years The concentration of beta trace protein decreased with increasing number of years of use of a wireless phone yielding a negative beta coefficient 0 32 95 confidence interval 0 60 to 0 04 Also cumulative use in hours gave a negative beta coefficient although not statistically significant Of the 62 persons 40 participated in an experimental study with 30 min exposure to an 890 MHz GSM signal No statistically significant change of beta trace protein was found In a similar study of the remaining 22 participitants with no exposure beta trace protein increased significantly over time probably due to a relaxed situation EMF emissions may down regulate the synthesis of beta trace protein This mechanism might be involved in sleep disturbances reported in persons exposed to RF fields The results must be interpreted with caution since use of mobile and cordless phones were self reported Awareness of exposure condition in the experimental study may have influenced beta trace protein concentrations
- ItemUse of wireless phones and serum β-trace protein in randomly recruited persons aged 18-65 years: a cross-sectional study.(2012-11-08) Söderqvist, Fredrik; Carlberg, Michael; Zetterberg, Henrik; Hardell, LennartBACKGROUND There are studies suggesting effects on sleep from pulse modulated radiofrequency fields used in mobile and cordless phones So far reports of adverse effects in observational studies are of limited value for risk assessment while effects from experimental studies seem to be more consistent but unclear as to their importance for health The aim of this study was to investigate whether use of wireless phones is associated with lower concentrations of trace protein lipocalin type prostaglandin D synthase a key enzyme in the synthesis of prostaglandin D 2 an endogenous sleep promoting neurohormone METHODS Three hundred and fourteen people aged 18 65 years and living in the municipality of rebro Sweden were recruited randomly using the population registry Total and age specific linear regression analyses adjusted for known covariates were used to calculate associations between levels of trace protein and short and long term use of wireless phones RESULTS Overall no statistically significant association between use of wireless phones and the serum concentration of trace protein was found neither with respect to short term nor long term use Age specific analyses however yielded negative associations for long term use cumulative hours of use and trace protein in the youngest age group 18 30 years CONCLUSION This study provided no overall evidence of an association between wireless phone use and serum concentrations of trace protein While the findings in the 18 30 year age group indicating lower concentrations with more cumulative hours of use should be further investigated no causal inferences can be made from the results of the present study