Browsing by Author "Vittinghoff, Eric"
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- ItemInnovation to motivation--pilot study of a mobile phone intervention to increase physical activity among sedentary women.(2010-09-14) Fukuoka, Yoshimi; Vittinghoff, Eric; Jong, So Son; Haskell, WilliamOBJECTIVES This uncontrolled pilot study assessed changes in pedometer measured step counts and self reported physical activity during a 3 week mobile phone based intervention We also explored whether age BMI and psychosocial factors were associated with changes in step counts METHODS Forty one sedentary adult women in San Francisco California were asked to report their pedometer steps using a study supplied mobile phone from June to September 2008 In the second and third weeks daily prompts delivered by the mobile phone encouraged participants to increase steps by 20 from the previous week RESULTS Mean age was 48 years Average daily total steps increased by approximately 800 or 15 over three weeks pUnder0 001 Lower BMI no antidepressant use and lower self reported health status were associated with higher step counts at baseline Improvements in self reported will power were associated with increases in step counts pUnder0 001 Neither age p 0 55 nor BMI p 0 13 was significantly associated with changes in activity over the 3 weeks CONCLUSIONS The intervention appeared to motivate sedentary women to increase their physical activity A randomized controlled clinical trial is warranted and feasible
- ItemA Mobile Health Strategy to Support Adherence to Antiretroviral Preexposure Prophylaxis.(0000-00-00) Fuchs, Jonathan D; Stojanovski, Kristefer; Vittinghoff, Eric; McMahan, Vanessa M; Hosek, Sybill G; Amico, K Rivet; Kouyate, Aminta; Gilmore, Hailey J; Buchbinder, Susan P; Lester, Richard T; Grant, Robert M; Liu, Albert YPreexposure prophylaxis is a highly protective HIV prevention strategy yet nonadherence can significantly reduce its effectiveness We conducted a mixed methods evaluation of a mobile health intervention iText that utilized weekly bidirectional text or e mail support messages to encourage preexposure prophylaxis PrEP adherence among participants in the multi site iPrEx open label extension study A convenience sample of PrEP users from the San Francisco and Chicago sites participated in a 12 week pilot study Fifty six men who have sex with men were enrolled a quarter of them were less than 30 years of age 13 were black African American 11 were Latino and most 88 completed some college Two thirds opted for text message delivery Of the 667 messages sent only 1 individual requested support initial nonresponse was observed in 22 and was higher among e mail compared to text message recipients Poststudy a majority of participants would recommend the intervention to others especially during PrEP initiation Moreover younger participants and men of color were more likely to report that they would use the iText strategy if it were available to them Several participants commented that while they were aware that the messages were automated they felt supported and encouraged that someone was always there Study staff reported that the intervention is feasible to administer and can be incorporated readily into clinic flow A pre post intervention regression discontinuity analysis using clinic based pill counts showed a 50 reduction in missed doses 95 confidence interval CI 16 71 p 0 008 and 77 95 CI 33 92 p 0 007 when comparing pill counts at quarterly visits just before and after iText enrollment A mobile health intervention using weekly bidirectional messaging was highly acceptable and demonstrated promising effects on PrEP adherence warranting further evaluation for efficacy in a randomized controlled trial
- ItemThe mPED randomized controlled clinical trial: applying mobile persuasive technologies to increase physical activity in sedentary women protocol.(2012-03-07) Fukuoka, Yoshimi; Komatsu, Judith; Suarez, Larry; Vittinghoff, Eric; Haskell, William; Noorishad, Tina; Pham, KristinBACKGROUND Despite the significant health benefits of regular physical activity approximately half of American adults particularly women and minorities do not meet the current physical activity recommendations Mobile phone technologies are readily available easily accessible and may provide a potentially powerful tool for delivering physical activity interventions However we need to understand how to effectively apply these mobile technologies to increase and maintain physical activity in physically inactive women The purpose of this paper is to describe the study design and protocol of the mPED mobile phone based physical activity education randomized controlled clinical trial that examines the efficacy of a 3 month mobile phone and pedometer based physical activity intervention and compares two different 6 month maintenance interventions METHODS A randomized controlled trial RCT with three arms 1 PLUS 3 month mobile phone and pedometer based physical activity intervention and 6 month mobile phone diary maintenance intervention 2 REGULAR 3 month mobile phone and pedometer based physical activity intervention and 6 month pedometer maintenance intervention and 3 CONTROL pedometer only but no intervention will be conducted A total of 192 physically inactive women who meet all inclusion criteria and successfully complete a 3 week run in will be randomized into one of the three groups The mobile phone serves as a means of delivering the physical activity intervention setting individualized weekly physical activity goals and providing self monitoring activity diary immediate feedback and social support The mobile phone also functions as a tool for communication and real time data capture The primary outcome is objectively measured physical activity DISCUSSION If efficacy of the intervention with a mobile phone is demonstrated the results of this RCT will be able to provide new insights for current behavioral sciences and mHealth TRIAL REGISTRATION ClinicalTrials gov NCTO1280812
- ItemRandomized Controlled Trial of a Mobile Health Intervention to Promote Retention and Adherence to Pre-exposure Prophylaxis among Young People at Risk for Human Immunodeficiency Virus: The EPIC Study.(0000-00-00) Liu, Albert Y; Vittinghoff, Eric; von Felten, Patricia; Amico, K Rivet; Anderson, Peter L; Lester, Richard; Andrew, Erin; Estes, Ixchell; Serrano, Pedro; Brothers, Jennifer; Buchbinder, Susan; Hosek, Sybil; Fuchs, Jonathan DBackground Young men who have sex with men MSM are among the most vulnerable to HIV infection in the United States While pre exposure prophylaxis PrEP has demonstrated effectiveness adherence and retention in care have been low among youth Methods We conducted a randomized controlled trial to evaluate the impact of a youth tailored bi directional text messaging PrEP support intervention PrEPmate on study retention and PrEP adherence Young individuals at risk for HIV acquisition initiating PrEP within Chicago s safety net hospital system were randomized 2 1 to receive PrEPmate or standard of care SoC for 36 weeks The primary retention outcome was study visit completion and the primary adherence outcome was tenofovir diphosphate TFV DP concentrations 700 fmol punch consistent with 4 doses week assessed at 4 12 24 and 36 weeks The impact of PrEPmate on retention and adherence was evaluated using generalized estimating equation logistic models with robust standard errors Results From April 2015 to March 2016 121 participants enrolled mean age 24 27 Black 36 Latino Across all visits participants who received PrEPmate were more likely to attend study visits 86 PrEPmate vs 71 SoC OR 2 62 95 CI 1 24 5 54 and have TFV DP levels consistent with 4 doses week 72 PrEPmate vs 57 SoC OR 2 05 95 CI 1 06 3 94 PrEPmate efficacy did not differ significantly by age race ethnicity education or insurance Overall 88 reported PrEPmate to be very somewhat helpful and 92 would recommend PrEPmate to others Conclusions An interactive text messaging intervention had high acceptability and significantly increased study visit retention and PrEP adherence among young individuals at risk for HIV acquisition