Browsing by Author "Velayati, Ali Akbar"
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- ItemThe Effect of Garcin® in Preventing AntiTB-Induced Hepatitis in Newly Diagnosed Tuberculosis Patients.(2014-04-08) Tabarsi, Payam; Fahimi, Fanak; Heidarzadeh, Nader; Haghgoo, Roodabeh; Kazempour, Mehdi; Masjedi, Mohammadreza; Velayati, Ali AkbarAdverse effects of antituberculosis agents such as hepatotoxicity may reduce treatment effectiveness because they significantly contribute to nonadherence and eventually result in treatment failure relapse or the emergence of drug resistance Garlic is an ancient herbal substance which its effectiveness on isoniazid and rifampicin induced hepatic injury in animal models has been demonstrated 1 In the present study a randomized double blind placebo controlled parallel group clinical trial was designed to assess the effect s of garlic tablets 1000 mg daily administered for two weeks orally Fifty eight newly diagnosed smear positive pulmonary tuberculosis patients with age ranges between 18 65 years old were randomly allocated into two groups Each patient received either garlic or placebo tablets for the first two weeks of tuberculosis treatment Of total 58 patients 31 received garlic tablets while 27 received placebo No significant difference was found between the two groups regarding age sex nationality smoking underlying diseases and opium usage During 8 weeks of anti TB antituberculosis treatment 8 13 0 patients developed drug induced hepatotoxicity DIH Of them 6 75 occurred in the first two weeks of treatment Fifty percent of the patients who developed DIH were in garlic group Results indicated no significant difference between groups in developing DIH p 1 000 We could not show a significant role in preventing DIH by 1000 mg daily garlic administration
- ItemEffect of pulmonary hypertension on outcome of pulmonary tuberculosis.(2014-09-11) Marjani, Majid; Baghaei, Parvaneh; Malekmohammad, Majid; Tabarsi, Payam; Sharif-Kashani, Babak; Behzadnia, Neda; Mansouri, Davood; Masjedi, Mohammad Reza; Velayati, Ali AkbarThis study performed at the National Research Institute of Tuberculosis and Lung Disease Tehran Iran aimed to evaluate the effect of concomitant pulmonary hypertension on the outcome of pulmonary tuberculosis