Browsing by Author "Thompson, Paul M"
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- ItemAPOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease.(2011-03-07) Pievani, Michela; Galluzzi, Samantha; Thompson, Paul M; Rasser, Paul E; Bonetti, Matteo; Frisoni, Giovanni BPrior studies reported that the hippocampal volume is smaller in Alzheimer s disease patients carrying the Apolipoprotein E 4 allele APOE4 versus patients who are non carriers of this allele This effect however has not been detected consistently possibly because of the regionally specific involvement of the hippocampal formation in Alzheimer s disease The aim of this study was to analyze the local effect of APOE4 on hippocampal atrophy in Alzheimer s disease patients Using high resolution T1 weighted images we investigated 14 patients heterozygous for the 4 allele age 72 8 SD years MMSE 20 4 SD and 14 patients not carrying the 4 allele age 71 10 MMSE 20 5 SD and 28 age sex and education matched controls age 71 8 MMSE 29 1 SD The hippocampal formation was outlined with manual tracing and 3D parametric surface models were created for each subject Radial atrophy was assessed on the whole hippocampal surface using the UCLA mapping technique E4 carriers and non carriers did not differ in their level of impairment in global cognition p 0 91 Mann Whitney test or memory p 0 29 Hippocampal surface analysis showed the typical pattern of CA1 and subicular tissue atrophy in both 4 carriers and non carriers compared with controls e4 carriers pUnder0 0002 4 non carriers pUnder0 01 permutation test The left hippocampal volume was significantly smaller in 4 carriers than non carriers p 0 044 Mann Whitney test the effect of APOE4 mapping to the subicular CA1 region p 0 041 permutation test Differences were not statistically significant in the right hippocampus p 0 20 permutation test These findings show that hippocampal atrophy is greater in APOE4 carriers in regions typically affected by pathology APOE4 may affect the structural expression of Alzheimer s disease
- ItemHippocampal and amygdalar local structural differences in elderly patients with schizophrenia.(2014-12-16) Prestia, Annapaola; Cavedo, Enrica; Boccardi, Marina; Muscio, Cristina; Adorni, Andrea; Geroldi, Cristina; Bonetti, Matteo; Thompson, Paul M; Frisoni, Giovanni BMorphological abnormalities have been reported for the hippocampi and amygdalae in young schizophrenia patients but very little is known about the pattern of abnormalities in elderly schizophrenia patients Here we investigated local structural differences in the hippocampi and amygdalae of elderly schizophrenia patients compared with healthy elderly subjects We also related these differences to clinical symptom severity
- ItemThe in vivo topography of cortical changes in healthy aging and prodromal Alzheimer's disease.(2013-09-23) Prestia, Annapaola; Baglieri, Annalisa; Pievani, Michela; Bonetti, Matteo; Rasser, Paul E; Thompson, Paul M; Marino, Silvia; Bramanti, Placido; Frisoni, Giovanni BGray matter atrophy is regarded as a valid marker of neurodegeneration in Alzheimer s disease AD but few studies have investigated in detail the topographic changes associated with normal aging In addition few studies have compared the changes in the earliest clinical stage of AD prodromal AD pAD with those of healthy aging Here we aimed to investigate the topographical distribution of age related cortical atrophy and to compare it with that associated with prodromal and estabilished AD
- ItemMedial temporal atrophy in early and late-onset Alzheimer's disease.(2014-06-10) Cavedo, Enrica; Pievani, Michela; Boccardi, Marina; Galluzzi, Samantha; Bocchetta, Martina; Bonetti, Matteo; Thompson, Paul M; Frisoni, Giovanni BLate onset and early onset Alzheimer s disease LOAD EOAD affect different neural systems and may be separate nosographic entities The most striking differences are in the medial temporal lobe severely affected in LOAD and relatively spared in EOAD We assessed amygdalar morphology and volume in 18 LOAD and 18 EOAD patients and 36 aged matched controls and explored their relationship with the hippocampal volume Three dimensional amygdalar shape was reconstructed with the radial atrophy mapping technique hippocampal volume was measured using a manual method Atrophy was greater in LOAD than EOAD 25 versus 17 in the amygdala and 20 versus 13 in the hippocampus In the amygdala LOAD showed significantly greater tissue loss than EOAD in the right dorsal central lateral and basolateral nuclei 20 30 loss p Under 0 03 all known to be connected to limbic regions In LOAD but not EOAD greater hippocampal atrophy was associated with amygdalar atrophy in the left dorsal central and medial nuclei r 0 6 p Under 0 05 also part of the limbic system These findings support the notion that limbic involvement is a prominent feature of LOAD but not EOAD
- ItemOccipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease.(2015-02-03) Babiloni, Claudio; Del Percio, Claudio; Boccardi, Marina; Lizio, Roberta; Lopez, Susanna; Carducci, Filippo; Marzano, Nicola; Soricelli, Andrea; Ferri, Raffaele; Triggiani, Antonio Ivano; Prestia, Annapaola; Salinari, Serenella; Rasser, Paul E; Basar, Erol; Famà, Francesco; Nobili, Flavio; Yener, Görsev; Emek-Savaş, Derya Durusu; Gesualdo, Loreto; Mundi, Ciro; Thompson, Paul M; Rossini, Paolo M; Frisoni, Giovanni BOccipital sources of resting state electroencephalographic EEG alpha rhythms are abnormal at the group level in patients with amnesic mild cognitive impairment MCI and Alzheimer s disease AD Here we evaluated the hypothesis that amplitude of these occipital sources is related to neurodegeneration in occipital lobe as measured by magnetic resonance imaging Resting state eyes closed EEG rhythms were recorded in 45 healthy elderly Nold 100 MCI and 90 AD subjects Neurodegeneration of occipital lobe was indexed by weighted averages of gray matter density estimated from structural MRIs EEG rhythms of interest were alpha 1 8 10 5 Hz and alpha 2 10 5 13 Hz EEG cortical sources were estimated by low resolution brain electromagnetic tomography Results showed a positive correlation between occipital gray matter density and amplitude of occipital alpha 1 sources in Nold MCI and AD subjects as a whole group r 0 3 p 0 000004 N 235 Furthermore there was a positive correlation between the amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Examination score across all subjects r 0 38 p 0 000001 N 235 Finally amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects sensitivity 87 8 specificity 66 7 area under the receiver operating characteristic curve 0 81 These results suggest that the amplitude of occipital sources of resting state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging
- ItemThe topography of grey matter involvement in early and late onset Alzheimer's disease.(2007-03-09) Frisoni, Giovanni B; Pievani, Michela; Testa, Cristina; Sabattoli, Francesca; Bresciani, Lorena; Bonetti, Matteo; Beltramello, Alberto; Hayashi, Kiralee M; Toga, Arthur W; Thompson, Paul MClinical observations have suggested that the neuropsychological profile of early and late onset forms of Alzheimer s disease EOAD and LOAD differ in that neocortical functions are more affected in the former and learning in the latter suggesting that they might be different diseases The aim of this study is to assess the brain structural basis of these observations and test whether neocortical areas are more heavily affected in EOAD and medial temporal areas in LOAD Fifteen patients with EOAD and 15 with LOAD onset before and after age 65 Mini Mental State Examination 19 8 SD 4 0 and 20 7 SD 4 2 were assessed with a neuropsychological battery and high resolution MRI together with 1 1 age and sex matched controls Cortical atrophy was assessed with cortical pattern matching and hippocampal atrophy with region of interest based analysis EOAD patients performed more poorly than LOAD on visuospatial frontal executive and learning tests EOAD patients had the largest atrophy in the occipital 25 grey matter GM loss in the left and 24 in the right hemisphere and parietal lobes 23 loss on both sides while LOAD patients were remarkably atrophic in the hippocampus 21 and 22 loss Hippocampal GM loss of EOAD 9 and 16 to the left and right and occipital 12 and 14 and parietal 13 and 12 loss of LOAD patients were less marked In EOAD GM loss of 25 or more was mapped to large neocortical areas and affected all lobes with relative sparing of primary sensory motor and visual cortex and anterior cingulate and orbital cortex In LOAD GM loss was diffusely milder below 15 losses of 15 20 were confined to temporoparietal and retrosplenial cortex and reached 25 in restricted areas of the medial temporal lobe and right superior temporal gyrus These findings indicate that EOAD and LOAD differ in their typical topographic patterns of brain atrophy suggesting different predisposing or aetiological factors