Browsing by Author "Rodriguez, A"
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- ItemEffectiveness and tolerability of a once-daily amprenavir/ritonavir-containing highly active antiretroviral therapy regimen in antiretroviral-naïve patients at risk for nonadherence: 48-week results after...(2004-09-16) Jayaweera, D T; Kolber, M A; Brill, M; Tanner, T; Campo, R; Rodriguez, A; Chu, H-M; Garg, VOBJECTIVES To determine the safety and effectiveness of a once daily highly active antiretroviral therapy HAART regimen in patients at risk for poor adherence using directly observed therapy DOT for 24 weeks followed by weekly phone contact for another 24 weeks METHODS A prospective open label pilot study was carried out Antiretroviral na ve patients with advanced HIV disease were treated with once daily amprenavir 1200 mg ritonavir 200 mg didanosine 400 mg and lamivudine 300 mg After 24 weeks DOT was substituted by weekly phone contact Measurements of viral load and CD4 cell count and safety laboratory measurements were taken regularly for 48 weeks RESULTS Twenty two patients were enrolled in the study of whom 19 completed at least 4 weeks of treatment Seventeen patients completed 24 weeks and 13 completed 48 weeks None discontinued treatment as a result of adverse events The median baseline HIV viral load was 5 29 log 10 HIV 1 RNA copies mL and the median CD4 cell count was 20 cells microL At weeks 24 and 48 74 of the patients had viral loads Under400 copies mL At 48 weeks the median decrease in viral load from baseline was 3 06 log 10 copies mL and the median increase in CD4 cell count was 118 cells microL The median trough plasma amprenavir concentrations at weeks 1 and 24 were 1 87 and 1 42 microg mL respectively CONCLUSIONS This study suggests that DOT followed by weekly patient contact results in good treatment outcome in this challenging population The median trough plasma amprenavir concentrations were above the effective concentration of drug that resulted in 90 inhibition of viral load in vivo EC 90 for wild type HIV
- ItemMobile technologies in the management of disasters: the results of a telemedicine solution.(2002-02-04) Cabrera, M F; Arredondo, M T; Rodriguez, A; Quiroga, JNowadays a great number of applications are used to compile and transmit casualties and disasters information but there are many troubles associated with the technology as can be the communications reliability and the size and weight of the devices medical staff has to carry with Telecommunication infrastructures support information movement among geographically dispersed locations Recently a large family of little devices has appeared in the buyer s market They are called Personal Digital Assistants and because of their physic and technical features they are very useful in the emergency field As for the communications reliability many technologies have been developed in the last years but it is necessary to find a solution that can be used in whatever situation independently of the emergency circumstances Facing this reality the Spanish government funded REMAF an ATYCA Initiative of Support for the Technology Security and Quality in the Industry project REMAF joined research groups UPM phone operators Fundaci n Airtel M vil and end users SAMUR to build a disaster data management system conceived to use modern telemedicine systems to optimize the management in these situations taking the advantage of the above mentioned mobile communication tools and networks
- ItemTransmission trials with a support system for the treatment of cardiac arrest outside hospital.(2001-09-28) Rodriguez, A; Villalar, J L; Arredondo, M T; Cabrera, M F; Del Pozo, FA mobile electrocardiogram ECG transmission system was developed which could transmit single lead ECG data via GSM mobile telephony Ambulance transmission trials comprised a total of 72 communications of which 94 were successful The system was able to redial up to a predetermined number of times until the GSM call was re established during the trials this value was set to five The average number of GSM call tries was 1 3 per connection The mean time required to establish a connection was 45 s the minimum was 34 s when only one attempt was needed to establish a GSM call The average duration of ECG transmission between communication breakdowns was 5 min 12 s When a link breakdown occurred the user had to wait for an average of only 42 s to continue monitoring the signal