Browsing by Author "Prestia, Annapaola"
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- ItemHippocampal and amygdalar local structural differences in elderly patients with schizophrenia.(2014-12-16) Prestia, Annapaola; Cavedo, Enrica; Boccardi, Marina; Muscio, Cristina; Adorni, Andrea; Geroldi, Cristina; Bonetti, Matteo; Thompson, Paul M; Frisoni, Giovanni BMorphological abnormalities have been reported for the hippocampi and amygdalae in young schizophrenia patients but very little is known about the pattern of abnormalities in elderly schizophrenia patients Here we investigated local structural differences in the hippocampi and amygdalae of elderly schizophrenia patients compared with healthy elderly subjects We also related these differences to clinical symptom severity
- ItemHippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia.(2011-05-02) Prestia, Annapaola; Boccardi, Marina; Galluzzi, Samantha; Cavedo, Enrica; Adorni, Andrea; Soricelli, Andrea; Bonetti, Matteo; Geroldi, Cristina; Giannakopoulos, Panteleimon; Thompson, Paul; Frisoni, GiovanniPatients with Alzheimer s disease AD and schizophrenia display cognitive behavioural disturbances and morphological abnormalities Although these latter reflect progressive neurodegeneration in AD their significance in schizophrenia is still unclear We explored the patterns of hippocampal and amygdalar atrophy in those patients and their associations with clinical parameters Structural magnetic resonance imaging was performed in 20 elderly schizophrenia patients 20 AD and 19 healthy older controls Hippocampal and amygdalar volumes were obtained by manual segmentation with a standardized protocol and compared among groups In both schizophrenia and AD patients left hippocampal and amygdalar volumes were significantly smaller The hippocampus amygdala ratio was significantly lower in schizophrenia compared to both AD cases 2 4 bilaterally 95 C I 2 2 to 2 7 and healthy controls bilaterally 2 5 95 C I 2 3 to 2 9 in left and 2 7 95 C I 2 4 to 3 1 in right hemisphere In schizophrenia patients a significant positive correlation was found between age at disease onset and the right hippocampus amygdala volume ratio Spearman rho 0 56 Negative symptoms correlated with higher right left amygdala volume ratio Spearman s rho 0 43 Our data show that unlike AD the hippocampus amygdala ratio is abnormally low and correlates with the age at onset in schizophrenia being a neurodevelopmental signature of the disease
- ItemThe in vivo topography of cortical changes in healthy aging and prodromal Alzheimer's disease.(2013-09-23) Prestia, Annapaola; Baglieri, Annalisa; Pievani, Michela; Bonetti, Matteo; Rasser, Paul E; Thompson, Paul M; Marino, Silvia; Bramanti, Placido; Frisoni, Giovanni BGray matter atrophy is regarded as a valid marker of neurodegeneration in Alzheimer s disease AD but few studies have investigated in detail the topographic changes associated with normal aging In addition few studies have compared the changes in the earliest clinical stage of AD prodromal AD pAD with those of healthy aging Here we aimed to investigate the topographical distribution of age related cortical atrophy and to compare it with that associated with prodromal and estabilished AD
- ItemMild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression.(2015-02-03) Caroli, Anna; Prestia, Annapaola; Galluzzi, Samantha; Ferrari, Clarissa; van der Flier, Wiesje M; Ossenkoppele, Rik; Van Berckel, Bart; Barkhof, Frederik; Teunissen, Charlotte; Wall, Anders E; Carter, Stephen F; Schöll, Michael; Choo, Il Han; Grimmer, Timo; Redolfi, Alberto; Nordberg, Agneta; Scheltens, Philip; Drzezga, Alexander; Frisoni, Giovanni B; ,The aim of this study was to investigate predictors of progressive cognitive deterioration in patients with suspected non Alzheimer disease pathology SNAP and mild cognitive impairment MCI
- ItemOccipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease.(2015-02-03) Babiloni, Claudio; Del Percio, Claudio; Boccardi, Marina; Lizio, Roberta; Lopez, Susanna; Carducci, Filippo; Marzano, Nicola; Soricelli, Andrea; Ferri, Raffaele; Triggiani, Antonio Ivano; Prestia, Annapaola; Salinari, Serenella; Rasser, Paul E; Basar, Erol; Famà, Francesco; Nobili, Flavio; Yener, Görsev; Emek-Savaş, Derya Durusu; Gesualdo, Loreto; Mundi, Ciro; Thompson, Paul M; Rossini, Paolo M; Frisoni, Giovanni BOccipital sources of resting state electroencephalographic EEG alpha rhythms are abnormal at the group level in patients with amnesic mild cognitive impairment MCI and Alzheimer s disease AD Here we evaluated the hypothesis that amplitude of these occipital sources is related to neurodegeneration in occipital lobe as measured by magnetic resonance imaging Resting state eyes closed EEG rhythms were recorded in 45 healthy elderly Nold 100 MCI and 90 AD subjects Neurodegeneration of occipital lobe was indexed by weighted averages of gray matter density estimated from structural MRIs EEG rhythms of interest were alpha 1 8 10 5 Hz and alpha 2 10 5 13 Hz EEG cortical sources were estimated by low resolution brain electromagnetic tomography Results showed a positive correlation between occipital gray matter density and amplitude of occipital alpha 1 sources in Nold MCI and AD subjects as a whole group r 0 3 p 0 000004 N 235 Furthermore there was a positive correlation between the amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Examination score across all subjects r 0 38 p 0 000001 N 235 Finally amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects sensitivity 87 8 specificity 66 7 area under the receiver operating characteristic curve 0 81 These results suggest that the amplitude of occipital sources of resting state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging