Browsing by Author "Miyakoshi, Junji"
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- Item2-GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells.(2010-05-27) Sekijima, Masaru; Takeda, Hiroshi; Yasunaga, Katsuaki; Sakuma, Noriko; Hirose, Hideki; Nojima, Toshio; Miyakoshi, JunjiWe investigated the mechanisms by which radiofrequency RF fields exert their activity and the changes in both cell proliferation and the gene expression profile in the human cell lines A172 glioblastoma H4 neuroglioma and IMR 90 fibroblasts from normal fetal lung following exposure to 2 1425 GHz continuous wave CW and Wideband Code Division Multiple Access W CDMA RF fields at three field levels During the incubation phase cells were exposed at the specific absorption rates SARs of 80 250 or 800 mW kg with both CW and W CDMA RF fields for up to 96 h Heat shock treatment was used as the positive control No significant differences in cell growth or viability were observed between any test group exposed to W CDMA or CW radiation and the sham exposed negative controls Using the Affymetrix Human Genome Array only a very small Under 1 number of available genes ca 16 000 to 19 000 exhibited altered expression in each experiment The results confirm that low level exposure to 2 1425 GHz CW and W CDMA RF fields for up to 96 h did not act as an acute cytotoxicant in either cell proliferation or the gene expression profile These results suggest that RF exposure up to the limit of whole body average SAR levels as specified in the ICNIRP guidelines is unlikely to elicit a general stress response in the tested cell lines under these conditions
- ItemEffects of radiofrequency electromagnetic fields on the human nervous system.(2010-02-25) van Rongen, Eric; Croft, Rodney; Juutilainen, Jukka; Lagroye, Isabelle; Miyakoshi, Junji; Saunders, Richard; de Seze, René; Tenforde, Thomas; Verschaeve, Luc; Veyret, Bernard; Xu, ZhengpingThe effects of exposure to radiofrequency electromagnetic fields EMF specifically related to the use of mobile telephones on the nervous system in humans have been the subject of a large number of experimental studies in recent years There is some evidence of an effect of exposure to a Global System for Mobile Telecommunication GSM type signal on the spontaneous electroencephalogram EEG This is not corroborated however by the results from studies on evoked potentials Although there is some evidence emerging that there may be an effect of exposure to a GSM type signal on sleep EEG results are still variable In summary exposure to a GSM type signal may result in minor effects on brain activity but such changes have never been found to relate to any adverse health effects No consistent significant effects on cognitive performance in adults have been observed If anything any effect is small and exposure seems to improve performance Effects in children did not differ from those in healthy adults Studies on auditory and vestibular function are more unequivocal neither hearing nor the sense of balance is influenced by short term exposure to mobile phone signals Subjective symptoms over a wide range including headaches and migraine fatigue and skin itch have been attributed to various radiofrequency sources both at home and at work However in provocation studies a causal relation between EMF exposure and symptoms has never been demonstrated There are clear indications however that psychological factors such as the conscious expectation of effect may play an important role in this condition