Browsing by Author "Kundi, Michael"
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- ItemCell phones and brain tumors: a review including the long-term epidemiologic data.(2009-08-06) Khurana, Vini G; Teo, Charles; Kundi, Michael; Hardell, Lennart; Carlberg, MichaelThe debate regarding the health effects of low intensity electromagnetic radiation from sources such as power lines base stations and cell phones has recently been reignited In the present review the authors attempt to address the following question is there epidemiologic evidence for an association between long term cell phone usage and the risk of developing a brain tumor Included with this meta analysis of the long term epidemiologic data are a brief overview of cell phone technology and discussion of laboratory data biological mechanisms and brain tumor incidence
- ItemThe controversy about a possible relationship between mobile phone use and cancer.(2010-08-30) Kundi, MichaelOver the last decade mobile phone use increased to almost 100 prevalence in many countries Evidence for potential health hazards accumulated in parallel by epidemiologic investigations has raised controversies about the appropriate interpretation and the degree of bias and confounding responsible for reduced or increased risk estimates Overall 33 epidemiologic studies were identified in the peer reviewed literature mostly 25 about brain tumors Methodologic considerations revealed that three important conditions for epidemiologic studies to detect an increased risk are not met no evidence based exposure metric is available the observed duration of mobile phone use is generally still too low no evidence based selection of end points among the grossly different types of neoplasias is possible because of lack of etiologic hypotheses The overall evidence speaks in favor of an increased risk but its magnitude cannot be assessed at present because of insufficient information on long term use
- ItemThe controversy about a possible relationship between mobile phone use and cancer.(2009-04-01) Kundi, MichaelDuring the last decade mobile phone use increased to almost 100 prevalence in many countries of the world Evidence for potential health hazards accumulated in parallel by epidemiologic investigations has raised controversies about the appropriate interpretation and the degree of bias and confounding responsible for reduced or increased risk estimates
- ItemMobile phone base stations-Effects on wellbeing and health.(2009-07-27) Kundi, Michael; Hutter, Hans-PeterStudying effects of mobile phone base station signals on health have been discouraged by authoritative bodies like WHO International EMF Project and COST 281 WHO recommended studies around base stations in 2003 but again stated in 2006 that studies on cancer in relation to base station exposure are of low priority As a result only few investigations of effects of base station exposure on health and wellbeing exist Cross sectional investigations of subjective health as a function of distance or measured field strength despite differences in methods and robustness of study design found indications for an effect of exposure that is likely independent of concerns and attributions Experimental studies applying short term exposure to base station signals gave various results but there is weak evidence that UMTS and to a lesser degree GSM signals reduce wellbeing in persons that report to be sensitive to such exposures Two ecological studies of cancer in the vicinity of base stations report both a strong increase of incidence within a radius of 350 and 400m respectively Due to the limitations inherent in this design no firm conclusions can be drawn but the results underline the urgent need for a comprehensive investigation of this issue Animal and in vitro studies are inconclusive to date An increased incidence of DMBA induced mammary tumors in rats at a SAR of 1 4W kg in one experiment could not be replicated in a second trial Indications of oxidative stress after low level in vivo exposure of rats could not be supported by in vitro studies of human fibroblasts and glioblastoma cells From available evidence it is impossible to delineate a threshold below which no effect occurs however given the fact that studies reporting low exposure were invariably negative it is suggested that power densities around 0 5 1mW m 2 must be exceeded in order to observe an effect The meager data base must be extended in the coming years The difficulties of investigating long term effects of base station exposure have been exaggerated considering that base station and handset exposure have almost nothing in common both needs to be studied independently It cannot be accepted that studying base stations is postponed until there is firm evidence for mobile phones
- ItemMobile phone specific electromagnetic fields induce transient DNA damage and nucleotide excision repair in serum-deprived human glioblastoma cells.(0000-00-00) Al-Serori, Halh; Ferk, Franziska; Kundi, Michael; Bileck, Andrea; Gerner, Christopher; Mišík, Miroslav; Nersesyan, Armen; Waldherr, Monika; Murbach, Manuel; Lah, Tamara T; Herold-Mende, Christel; Collins, Andrew R; Knasmüller, SiegfriedSome epidemiological studies indicate that the use of mobile phones causes cancer in humans in particular glioblastomas It is known that DNA damage plays a key role in malignant transformation therefore we investigated the impact of the UMTS signal which is widely used in mobile telecommunications on DNA stability in ten different human cell lines six brain derived cell lines lymphocytes fibroblasts liver and buccal tissue derived cells under conditions relevant for users SAR 0 25 to 1 00 W kg We found no evidence for induction of damage in single cell gel electrophoresis assays when the cells were cultivated with serum However clear positive effects were seen in a p53 proficient glioblastoma line U87 when the cells were grown under serum free conditions while no effects were found in p53 deficient glioblastoma cells U251 Further experiments showed that the damage disappears rapidly in U87 and that exposure induced nucleotide excision repair NER and does not cause double strand breaks DSBs The observation of NER induction is supported by results of a proteome analysis indicating that several proteins involved in NER are up regulated after exposure to UMTS additionally we found limited evidence for the activation of the interferon pathway The present findings show that the signal causes transient genetic instability in glioma derived cells and activates cellular defense systems
- ItemMobile phone use and brain cancer: is the association biased?(2010-08-17) Kundi, Michael
- ItemMobile phone use and risk of glioma in adults: conclusions are questionable.(2006-04-28) Kundi, Michael
- ItemMobile telephones and cancer--a review of epidemiological evidence.(2004-09-16) Kundi, Michael; Mild, Kjell; Hardell, Lennart; Mattsson, Mats-OlofThere is considerable public concern about possible long term adverse health effects of mobile phones While there is scientific controversy about long term health effects of high frequency electromagnetic fields lasting for at least 50 yr the rise and success of mobile telecommunication made it necessary to investigate the problem more comprehensively and assess the possible risk cautiously because never before in history has a substantial proportion of the population been exposed to microwaves in the near field and at comparably high levels Because the mostly localized exposure target region is the head most epidemiological studies focus on brain tumors Overall nine epidemiological studies have been published four from the United States two from Sweden and one each from Denmark Finland and Germany Seven studies were mainly on brain tumors with one investigating in addition to brain tumors salivary gland cancer and another cancer of the hematopoietic and lymphatic tissues and one examining intraocular melanoma All studies have some methodological deficiencies 1 too short duration of mobile phone use to be helpful in risk assessment 2 exposure was not rigorously determined and 3 there is a possibility of recall and response error in some studies Nevertheless all studies approaching reasonable latencies found an increased cancer risk associated with mobile phone use Estimates of relative risk in these studies vary between 1 3 and 4 6 with highest overall risk for acoustic neuroma 3 5 and uveal melanoma 4 2 and there is evidence for enhanced cancer risk with increasing latency and duration of mobile phone use
- ItemMobile telephones and cancer: is there really no evidence of an association? (review).(2003-06-06) Hansson Mild, Kjell; Hardell, Lennart; Kundi, Michael; Mattsson, Mats-OlofTwo Swedish epidemiological studies have shown an association between the use of mobile telephones mainly of the analogue type and brain tumours These findings have been corroborated in a Finnish study Supportive evidence has also come from studies in USA but these investigations as well as a Danish study are inconclusive due to e g few exposed subjects short latency periods and methodological shortcomings The Swedish Radiation Protection Authority SSI engaged two epidemiologists from a private company to conduct a review of the literature They claimed that use of mobile telephones is not associated with increased risk for brain tumours Their conclusion was however based on an unbalanced view of current literature in favour of studies showing no association These circumstances are further explored in this communication
- ItemPoor-to-moderate agreement between self and proxy interviews of mobile phone use.(2012-09-11) Hutter, Hans-Peter; Ehrenhöfer, Lisa; Freuis, Edith; Hartl, Patrik; Kundi, MichaelIn epidemiological studies cases cannot always be interviewed due to them being too ill or already deceased Under these circumstances proxy interviews are often conducted however the veridicality of information about mobile phone use gained by proxy interviews has been doubted The issue is undecided due to the lack of empirical data We conducted a study of 119 heterosexual couples Both partners answered two questionnaires about mobile phone use one about their own use and one about their partner s use Overall agreement assessed using Cohen s kappa Passing and Bablok regression and concordance coefficients between self and proxy data was poor to moderate e g concordance coefficients of 0 55 for duration of use The only item with good agreement was whether or not a prepaid phone was used Cohen s kappa 0 78 and 0 63 for male and female estimates respectively and to a lesser degree the onset of mobile phone use concordance coefficients of 0 66 and 0 61 Poorest agreement was obtained for the side of the head the mobile phone was held during calls kappa coefficients of 0 20 and 0 24 for female and male estimates respectively We conclude that the assessment of mobile phone use by proxy data cannot be relied on except for information about onset of mobile phone use use of prepaid or contract phones and to a lesser degree duration of daily use Agreement concerning the important information about side of the head the mobile phone is held during calls was poorest and only slightly better than chance
- ItemPublic perception of risk concerning celltowers and mobile phones.(2004-03-25) Hutter, Hans-Peter; Moshammer, Hanns; Wallner, Peter; Kundi, MichaelThe controversy about health risks of electromagnetic fields EMF has contributed in raising fears concerning emissions from celltowers The study was to examine whether or not neighbours of celltowers are particularly concerned about adverse health effects of mobile phones and their base stations
- ItemRe: "cellular telephone use and risk of acoustic neuroma".(2004-10-21) Kundi, Michael
- ItemRe: "Long-term mobile phone use and brain tumor risk".(2005-09-01) Hardell, Lennart; Mild, Kjell Hansson; Kundi, Michael
- ItemStudy of mobile phone use and glioma risk was fatally flawed.(2012-05-02) Kundi, Michael
- ItemTinnitus and mobile phone use.(2010-11-15) Hutter, Hans-Peter; Moshammer, Hanns; Wallner, Peter; Cartellieri, Monika; Denk-Linnert, Doris-Maria; Katzinger, Michaela; Ehrenberger, Klaus; Kundi, MichaelThe mechanisms that produce tinnitus are not fully understood While tinnitus can be associated with diseases and disorders of the ear retrocochlear diseases and vascular pathologies there are few known risk factors for tinnitus apart from these conditions There is anecdotal evidence of an link between mobile phone use and tinnitus but so far there have been no systematic investigations into this possible association