Browsing by Author "Ivanic, Joseph"
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- ItemEvidence of probabilistic behaviour in protein interaction networks.(2008-03-27) Ivanic, Joseph; Wallqvist, Anders; Reifman, JaquesData from high throughput experiments of protein protein interactions are commonly used to probe the nature of biological organization and extract functional relationships between sets of proteins What has not been appreciated is that the underlying mechanisms involved in assembling these networks may exhibit considerable probabilistic behaviour
- ItemUnraveling the conundrum of seemingly discordant protein-protein interaction datasets.(2010-11-24) Gupta, Shobhit; Wallqvist, Anders; Bondugula, Rajkumar; Ivanic, Joseph; Reifman, JaquesMost high throughput experimental results of protein protein interactions PPIs are seemingly inconsistent with each other In this article we re evaluated these contradictions within the context of the underlying domain domain interactions DDIs for two Escherichia coli and four Saccharomyces cerevisiae PPI datasets derived from high throughput yeast two hybrid and tandem affinity purification experimental platforms For shared DDIs across pairs of compared datasets we observed a remarkably high pair wise correlation Pearson correlation coefficient between 0 80 and 0 84 between datasets of the same organism derived from the same experimental platform To a lesser degree this concordance also held true for more general inter platform and intra species comparisons Pearson correlation coefficient between 0 52 and 0 89 Thus although varying experimental conditions can influence the ability of individual proteins to interact and therefore create apparent differences among PPIs the physical nature of the underlying interactions captured by DDIs is the same and can be used to model and predict PPIs