Browsing by Author "Granholm, Eric"
Now showing 1 - 3 of 3
Results Per Page
Sort Options
- ItemMobile Assessment and Treatment for Schizophrenia (MATS): a pilot trial of an interactive text-messaging intervention for medication adherence, socialization, and auditory hallucinations.(2012-04-20) Granholm, Eric; Ben-Zeev, Dror; Link, Peter C; Bradshaw, Kristen R; Holden, Jason LMobile Assessment and Treatment for Schizophrenia MATS employs ambulatory monitoring methods and cognitive behavioral therapy interventions to assess and improve outcomes in consumers with schizophrenia through mobile phone text messaging Three MATS interventions were developed to target medication adherence socialization and auditory hallucinations Participants received up to 840 text messages over a 12 week intervention period Fifty five consumers with schizophrenia or schizoaffective disorder were enrolled but 13 consumers with more severe negative symptoms lower functioning and lower premorbid IQ did not complete the intervention despite repeated prompting and training For completers the average valid response rate for 216 outcome assessment questions over the 12 week period was 86 and 86 of phones were returned undamaged Medication adherence improved significantly but only for individuals who were living independently Number of social interactions increased significantly and a significant reduction in severity of hallucinations was found In addition the probability of endorsing attitudes that could interfere with improvement in these outcomes was also significantly reduced in MATS Lab based assessments of more general symptoms and functioning did not change significantly This pilot study demonstrated that low intensity text messaging interventions like MATS are feasible and effective interventions to improve several important outcomes especially for higher functioning consumers with schizophrenia
- ItemMobile interventions for severe mental illness: design and preliminary data from three approaches.(2010-10-05) Depp, Colin A; Mausbach, Brent; Granholm, Eric; Cardenas, Veronica; Ben-Zeev, Dror; Patterson, Thomas L; Lebowitz, Barry D; Jeste, Dilip VMobile devices can be used to deliver psychosocial interventions yet there is little prior application in severe mental illness We provide the rationale design and preliminary data from 3 ongoing clinical trials of mobile interventions developed for bipolar disorder or schizophrenia Project 1 used a personal digital assistant to prompt engagement in personalized self management behaviors based on real time data Project 2 employed experience sampling through text messages to facilitate case management Project 3 was built on group functional skills training for schizophrenia by incorporating between session mobile phone contacts with therapists Preliminary findings were of minimal participant attrition and no broken devices yet several operational and technical barriers needed to be addressed Adherence was similar to that reported in nonpsychiatric populations with high participant satisfaction Therefore mobile devices seem feasible and acceptable in augmenting psychosocial interventions for severe mental illness with future research in establishing efficacy cost effectiveness and ethical and safety protocols
- ItemReal-time electronic ambulatory monitoring of substance use and symptom expression in schizophrenia.(2011-02-07) Swendsen, Joel; Ben-Zeev, Dror; Granholm, EricOBJECTIVE Despite evidence demonstrating elevated comorbidity between schizophrenia and substance use disorders the underlying mechanisms of association remain poorly understood The brief time intervals that characterize interactions between substance use and psychotic symptoms in daily life are inaccessible to standard research protocols The authors used electronic personal digital assistants PDAs to examine the temporal association of diverse forms of substance use with psychotic symptoms and psychological states in natural contexts METHOD Of 199 community dwelling individuals with schizophrenia or schizoaffective disorder who were contacted to participate in the study 92 accepted and 73 completed the study The 145 participants who completed the study provided reports of substance use psychotic symptoms mood and event negativity multiple times per day over 7 consecutive days through PDAs RESULTS Participants responded to 72 of the electronic interviews N 2 737 across daily life contexts Strong within day prospective associations were observed in both directions between substance use and negative psychological states or psychotic symptoms but considerable variation was observed by substance type Consistent with the notion of self medication alcohol use was most likely to follow increases in anxious mood or psychotic symptoms Cannabis and other illicit substances demonstrating more complex patterns were more likely to follow certain psychological states but were also associated with the later onset of psychotic symptoms CONCLUSIONS The dynamic interplay of substance use and psychotic symptoms is in many cases consistent with both causal and self medication mechanisms and these patterns of association should be considered in the design of treatment and prevention strategies