Browsing by Author "Geroldi, Cristina"
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- ItemAssociation of blood pressure and genetic background with white matter lesions in patients with mild cognitive impairment.(2008-05-30) Galluzzi, Samantha; Geroldi, Cristina; Benussi, Luisa; Ghidoni, Roberta; Testa, Cristina; Borsci, Genoveffa; Bonetti, Matteo; Manfellotto, Dario; Romanelli, Giuseppe; Zulli, Roberto; Binetti, Giuliano; Frisoni, Giovanni BBackground White matter lesions WMLs may contribute to cognitive deficits in patients with mild cognitive impairment MCI but their pathogenesis is complex Fluctuations of blood pressure BP over 24 hours and genetic predisposition to develop vascular damage have been implicated Methods In 63 MCI patients 65 years old or older BP was measured both clinically and with ambulatory BP monitoring Patients were classified in two groups no very mild n 34 and mild to severe n 29 WMLs based on a visual scale on magnetic resonance mean age 71 8 4 7 vs 74 6 5 1 and female gender 53 vs 66 respectively The volume of WMLs was measured by a semi automatic method separately for periventricular caps and rim periventricular confluent subcortical punctate and subcortical confluent Polymorphisms of cystatin C CST3 and cholesterol 24 hydroxylase CYP46 genes putative risk factors for cerebrovascular disease were determined Results The prevalence of cerebrovascular risk factors was similar in the two MCI groups of different WML severity as well as clinic and ambulatory BP In patients with mild to severe but not in those with no very mild WMLs the volume of periventricular confluent WMLs increased with increasing daytime systolic BP regression coefficient 47 95 confidence interval CI 13 to 71 vs 02 95 CI 32 to 36 p 003 for the difference between slopes The volume of other WML subtypes was not associated with ambulatory BP Participants carrying both CST3 B and CYP46 T alleles were overrepresented in the MCI group with mild to severe WMLs 43 vs 17 p 03 Conclusions BP and gene putative risk factors for cerebrovascular disease are differentially associated with WMLs in two MCI groups of different WML severity WMLs might develop for the convergence of innate with acquired factors
- ItemBrain perfusion correlates of medial temporal lobe atrophy and white matter hyperintensities in mild cognitive impairment.(2007-08-31) Caroli, Anna; Testa, Cristina; Geroldi, Cristina; Nobili, Flavio; Guerra, Ugo P; Bonetti, Matteo; Frisoni, Giovanni BTo assess the association of Medial Temporal lobe Atrophy MTA and White Matter Hyperintensities WMHs with gray matter perfusion in Mild Cognitive Impairment MCI
- ItemClinical and neuropsychological features associated with structural imaging patterns in patients with mild cognitive impairment.(2007-02-22) Rossi, Roberta; Geroldi, Cristina; Bresciani, Lorena; Testa, Cristina; Binetti, Giuliano; Zanetti, Orazio; Frisoni, Giovanni BTo describe the clinical and neuropsychological features of mild cognitive impairment MCI patients with medial temporal atrophy MTA white matter hyperintensities WMH both and neither and to assess whether the rate of progression differs among groups
- ItemDrug prescription in mild cognitive impairment: the physicians' perspective in Italy.(2006-10-30) Frisoni, Giovanni B; Canu, Elisa; Geroldi, Cristina; Zanetti, Orazio; Zacchi, ValeriaToday there are no data on the type of drugs prescribed to MCI patients nor the prevalence of their prescription The aim of this study was to describe which drugs were prescribed in 2004 for cognitive and non cognitive disturbances of patients with MCI in a sizable group of Italian expert centers for the diagnosis and treatment of Alzheimer s disease
- ItemHippocampal and amygdalar local structural differences in elderly patients with schizophrenia.(2014-12-16) Prestia, Annapaola; Cavedo, Enrica; Boccardi, Marina; Muscio, Cristina; Adorni, Andrea; Geroldi, Cristina; Bonetti, Matteo; Thompson, Paul M; Frisoni, Giovanni BMorphological abnormalities have been reported for the hippocampi and amygdalae in young schizophrenia patients but very little is known about the pattern of abnormalities in elderly schizophrenia patients Here we investigated local structural differences in the hippocampi and amygdalae of elderly schizophrenia patients compared with healthy elderly subjects We also related these differences to clinical symptom severity
- ItemHippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia.(2011-05-02) Prestia, Annapaola; Boccardi, Marina; Galluzzi, Samantha; Cavedo, Enrica; Adorni, Andrea; Soricelli, Andrea; Bonetti, Matteo; Geroldi, Cristina; Giannakopoulos, Panteleimon; Thompson, Paul; Frisoni, GiovanniPatients with Alzheimer s disease AD and schizophrenia display cognitive behavioural disturbances and morphological abnormalities Although these latter reflect progressive neurodegeneration in AD their significance in schizophrenia is still unclear We explored the patterns of hippocampal and amygdalar atrophy in those patients and their associations with clinical parameters Structural magnetic resonance imaging was performed in 20 elderly schizophrenia patients 20 AD and 19 healthy older controls Hippocampal and amygdalar volumes were obtained by manual segmentation with a standardized protocol and compared among groups In both schizophrenia and AD patients left hippocampal and amygdalar volumes were significantly smaller The hippocampus amygdala ratio was significantly lower in schizophrenia compared to both AD cases 2 4 bilaterally 95 C I 2 2 to 2 7 and healthy controls bilaterally 2 5 95 C I 2 3 to 2 9 in left and 2 7 95 C I 2 4 to 3 1 in right hemisphere In schizophrenia patients a significant positive correlation was found between age at disease onset and the right hippocampus amygdala volume ratio Spearman rho 0 56 Negative symptoms correlated with higher right left amygdala volume ratio Spearman s rho 0 43 Our data show that unlike AD the hippocampus amygdala ratio is abnormally low and correlates with the age at onset in schizophrenia being a neurodevelopmental signature of the disease
- ItemPrescription patterns and efficacy of drugs for patients with dementia: physicians' perspective in Italy.(2007-11-16) Frisoni, Giovanni B; Canu, Elisa; Geroldi, Cristina; Brignoli, Barbara; Anglani, Livio; Galluzzi, Samantha; Zacchi, Valeria; Zanetti, OrazioThe aim of this study was to assess the prescription practices and judgment of efficacy of physicians of drugs used for the cognitive and non cognitive symptoms of dementia