Browsing by Author "Fotiadis, Dimitrios I"
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- ItemAcceptability to patients, carers and clinicians of an mHealth platform for the management of Parkinson's disease (PD_Manager): study protocol for a pilot randomised controlled trial.(0000-00-00) Antonini, Angelo; Gentile, Giovanni; Giglio, Manuela; Marcante, Andrea; Gage, Heather; Touray, Morro M L; Fotiadis, Dimitrios I; Gatsios, Dimitris; Konitsiotis, Spyridon; Timotijevic, Lada; Egan, Bernadette; Hodgkins, Charo; Biundo, Roberta; Pellicano, Clelia; ,BACKGROUND Parkinson s disease is a degenerative neurological condition causing multiple motor and non motor symptoms that have a serious adverse effect on quality of life Management is problematic due to the variable and fluctuating nature of symptoms often hourly and daily The PD Manager mHealth platform aims to provide a continuous feed of data on symptoms to improve clinical understanding of the status of any individual patient and inform care planning The objectives of this trial are to 1 assess patient and family carer perspectives of PD Manager regarding comfort acceptability and ease of use 2 assess clinician views about the utility of the data generated by PD Manager for clinical decision making and the acceptability of the system in clinical practice METHODS DESIGN This trial is an unblinded parallel two group randomised controlled pilot study A total of 200 persons with Parkinson s disease Hoehn and Yahr stage 3 experiencing motor fluctuations at least 2 h per day with primary family carers in three countries 110 Rome 50 Venice Italy 20 each in Ioannina Greece and Surrey England will be recruited Following informed consent baseline information will be gathered including the following age gender education attitudes to technology patient and carer time since Parkinson s diagnosis symptom status and comorbidities patient only Randomisation will assign participants 1 1 in each country to PD Manager vs control stratifying by age 1 70 1 70 and gender 60 M 40 F The PD Manager system captures continuous data on motor symptoms sleep activity speech quality and emotional state using wearable devices wristband insoles and a smartphone with apps for storing and transmitting the information Control group participants will be asked to keep a symptom diary covering the same elements as PD Manager records After a minimum of two weeks each participant will attend a consultation with a specialist doctor for review of the data gathered by either means and changes to management will be initiated as indicated Patients carers and clinicians will be asked for feedback on the acceptability and utility of the data collection methods The PD Manager intervention compared to a symptom diary will be evaluated in a cost consequences framework DISCUSSION Information gathered will inform further development of the PD Manager system and a larger effectiveness trial TRIAL REGISTRATION ISRCTN Registry ISRCTN17396879 Registered on 15 March 2017
- ItemHeterogeneous data fusion and intelligent techniques embedded in a mobile application for real-time chronic disease management.(2012-01-18) Bellos, Christos; Papadopoulos, Athanassios; Rosso, Roberto; Fotiadis, Dimitrios ICHRONIOUS system is an integrated platform aiming at the management of chronic disease patients One of the most important components of the system is a Decision Support System DSS that has been developed in a Smart Device SD This component decides on patient s current health status by combining several data which are acquired either by wearable sensors or manually inputted by the patient or retrieved from the specific database In case no abnormal situation has been tracked the DSS takes no action and remains deactivated until next abnormal situation pack of data are being acquired or next scheduled data being transmitted The DSS that has been implemented is an integrated classification system with two parallel classifiers combining an expert system rule based system and a supervised classifier such as Support Vector Machines SVM Random Forests artificial Neural Networks aNN like the Multi Layer Perceptron Decision Trees and Na ve Bayes The above categorized system is useful for providing critical information about the health status of the patient
- ItemAn integrated telemedicine platform for the assessment of affective physiological states.(2006-09-13) Katsis, Christos D; Ganiatsas, George; Fotiadis, Dimitrios IAUBADE is an integrated platform built for the affective assessment of individuals The system performs evaluation of the emotional state by classifying vectors of features extracted from facial Electromyogram Respiration Electrodermal Activity and Electrocardiogram The AUBADE system consists of a a multisensorial wearable b a data acquisition and wireless communication module c a feature extraction module d a 3D facial animation module which is used for the projection of the obtained data through a generic 3D face model whereas the end user will be able to view the facial expression of the subject in real time e an intelligent emotion recognition module and f the AUBADE databases where the acquired signals along with the subject s animation videos are saved The system is designed to be applied to human subjects operating under extreme stress conditions in particular car racing drivers and also to patients suffering from neurological and psychological disorders AUBADE s classification accuracy into five predefined emotional classes high stress low stress disappointment euphoria and neutral face is 86 0 The pilot system applications and components are being tested and evaluated on Maserati s car racing drivers
- ItemTransosseous application of low-intensity ultrasound for the enhancement and monitoring of fracture healing process in a sheep osteotomy model.(2006-03-20) Malizos, Konstantinos N; Papachristos, Athanasios A; Protopappas, Vasilios C; Fotiadis, Dimitrios IThe purpose of this study is twofold a to investigate the application of transosseous low intensity pulsed ultrasound LiUS on the enhancement of fracture healing and b to demonstrate the ability of transosseous ultrasound propagation to monitor the healing process A midshaft tibial osteotomy model was used on 40 skeletally mature sheep and an external fixator was applied to maintain the reduction and stabilization of the osteotomy Two ultrasound transducers were implanted into the fracture site in contact with the bone For investigating the efficacy of LiUS the animals were randomly divided in two equal groups the treatment group and the control group The LiUS treated animals received 200 micros bursts of 1 MHz sine waves with a pulse repetition rate of 1 kHz and average intensity of 30 mW cm2 for 20 min daily For monitoring purposes an ultrasound dataset was constructed consisting of serial ultrasound measurements obtained from healing bones Animals sacrifice took place on the 100th post operative day The effect of LiUS on fracture healing was evaluated using radiographs destructive three point bending testing and quantitative CT based bone mineral density BMD measurements Survival analysis using Kaplan Meier curves showed significantly higher probability of radiographic healing for the animals in the treatment group P 0 009 Statistical significance was also observed for callus BMD P 0 003 Wilcoxon nonparametric test the breaking load P 0 001 extrinsic stiffness P 0 019 Young s modulus P 0 043 and ultimate strength P 0 051 in favor of the LiUS treated limbs Analysis of the obtained ultrasonic measurements showed that the propagation velocity across healing bones constitutes a significant feature able to early distinguish between healed and nonhealed bones area under ROC curve was 0 810 and 0 841 on the 80th and 100th post operative days respectively Both the LiUS application and the ultrasonic measurements are supported by an integrated telemedicine system which also incorporates an ultrasound wearable device and a patient management system
- ItemAn ultrasound wearable system for the monitoring and acceleration of fracture healing in long bones.(2005-09-29) Protopappas, Vasilios C; Baga, Dina A; Fotiadis, Dimitrios I; Likas, Aristidis C; Papachristos, Athanasios A; Malizos, Konstantinos NAn ultrasound wearable system for remote monitoring and acceleration of the healing process in fractured long bones is presented The so called USBone system consists of a pair of ultrasound transducers implanted into the fracture region a wearable device and a centralized unit The wearable device is responsible to carry out ultrasound measurements using the axial transmission technique and initiate therapy sessions of low intensity pulsed ultrasound The acquired measurements and other data are wirelessly transferred from the patient site to the centralized unit which is located in a clinical setting The evaluation of the system on an animal tibial osteotomy model is also presented A dataset was constructed for monitoring purposes consisting of serial ultrasound measurements follow up radiographs quantitative computed tomography based densitometry and biomechanical data The animal study demonstrated the ability of the system to collect ultrasound measurements in an effective and reliable fashion and participating orthopaedic surgeons accepted the system for future clinical application Analysis of the acquired measurements showed that the pattern of evolution of the ultrasound velocity through healing bones over the postoperative period monitors a dynamic healing process Furthermore the ultrasound velocity of radiographically healed bones returns to 80 of the intact bone value whereas the correlation coefficient of the velocity with the material and mechanical properties of the healing bone ranges from 0 699 to 0 814 The USBone system constitutes the first telemedicine system for the out hospital management of patients sustained open fractures and treated with external fixation devices