Browsing by Author "Filippi, Massimo"
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- ItemThe effect of white matter lesions on cognition in the elderly--small but detectable.(2007-11-05) Frisoni, Giovanni B; Galluzzi, Samantha; Pantoni, Leonardo; Filippi, MassimoThe extent to which white matter changes affect brain function in elderly individuals is a matter for debate Although there is a consensus that large confluent white matter lesions WMLs can be attributed to small vessel disease and might denote anatomical damage to axons the clinical effect of WMLs with regard to cognitive impairment is less certain In this Review we argue that WMLs are associated with greater detectable progressive cognitive deterioration than is normal aging but other causes of progressive cognitive deterioration such as Alzheimer s disease are associated with greater cognitive decline than are WMLs This view has important implications for the development of drugs for the treatment and prevention of cognitive impairment and dementia
- ItemMultiple sclerosis and Alzheimer disease through the looking glass of MR imaging.(2005-11-15) Frisoni, Giovanni B; Filippi, Massimo
- ItemSubregional basal forebrain atrophy in Alzheimer's disease: a multicenter study.(2014-04-25) Kilimann, Ingo; Grothe, Michel; Heinsen, Helmut; Alho, Eduardo Joaquim Lopez; Grinberg, Lea; Amaro, Edson; Dos Santos, Gláucia Aparecida Bento; da Silva, Rafael Emídio; Mitchell, Alex J; Frisoni, Giovanni B; Bokde, Arun L W; Fellgiebel, Andreas; Filippi, Massimo; Hampel, Harald; Klöppel, Stefan; Teipel, Stefan JHistopathological studies in Alzheimer s disease AD suggest severe and region specific neurodegeneration of the basal forebrain cholinergic system BFCS Here we studied the between center reliability and diagnostic accuracy of MRI based BFCS volumetry in a large multicenter data set including participants with prodromal n 41 or clinically manifest AD n 134 and 148 cognitively healthy controls Atrophy was determined using voxel based and region of interest based analyses of high dimensionally normalized MRI scans using a newly created map of the BFCS based on postmortem in cranio MRI and histology The AD group showed significant volume reductions of all subregions of the BFCS which were most pronounced in the posterior nucleus basalis Meynert NbM The mild cognitive impairment AD group showed pronounced volume reductions in the posterior NbM but preserved volumes of anterior medial regions Diagnostic accuracy of posterior NbM volume was superior to hippocampus volume in both groups despite higher multicenter variability of the BFCS measurements The data of our study suggest that BFCS morphometry may provide an emerging biomarker in AD
- ItemWhite matter lesions in the elderly: pathophysiological hypothesis on the effect on brain plasticity and reserve.(2008-09-01) Galluzzi, Samantha; Lanni, Cristina; Pantoni, Leonardo; Filippi, Massimo; Frisoni, Giovanni BThe effect of white matter lesions WMLs on the brain of elderly individuals is unclear Most debate has focused on the clinical effect of WMLs on cognitive impairment Large cross sectional and longitudinal clinic and population based studies suggest that the effect of WMLs on global cognitive performance is relatively small only individuals with the most severe degrees of WMLs having clinically relevant effects Here we review recent data suggesting that WMLs might affect brain function through impairment of brain plasticity and reserve The clinical effect consists in inability of the brain to respond to interventions such as psychotropic drug medications or rehabilitative interventions