Browsing by Author "Cheng, Li"
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- ItemAGeS: a software system for microbial genome sequence annotation.(2011-03-16) Kumar, Kamal; Desai, Valmik; Cheng, Li; Khitrov, Maxim; Grover, Deepak; Satya, Ravi Vijaya; Yu, Chenggang; Zavaljevski, Nela; Reifman, JaquesThe annotation of genomes from next generation sequencing platforms needs to be rapid high throughput and fully integrated and automated Although a few Web based annotation services have recently become available they may not be the best solution for researchers that need to annotate a large number of genomes possibly including proprietary data and store them locally for further analysis To address this need we developed a standalone software application the Annotation of microbial Genome Sequences AGeS system which incorporates publicly available and in house developed bioinformatics tools and databases many of which are parallelized for high throughput performance
- ItemDBSecSys: a database of Burkholderia mallei secretion systems.(2014-07-25) Memišević, Vesna; Kumar, Kamal; Cheng, Li; Zavaljevski, Nela; DeShazer, David; Wallqvist, Anders; Reifman, JaquesBacterial pathogenicity represents a major public health concern worldwide Secretion systems are a key component of bacterial pathogenicity as they provide the means for bacterial proteins to penetrate host cell membranes and insert themselves directly into the host cells cytosol Burkholderia mallei is a Gram negative bacterium that uses multiple secretion systems during its host infection life cycle To date the identities of secretion system proteins for B mallei are not well known and their pathogenic mechanisms of action and host factors are largely uncharacterized