Browsing by Author "Chassin, Ludovic J"
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- ItemClosing the loop: the adicol experience.(2004-06-16) Hovorka, Roman; Chassin, Ludovic J; Wilinska, Malgorzata E; Canonico, Valentina; Akwi, Joyce Akwe; Federici, Marco Orsini; Massi-Benedetti, Massimo; Hutzli, Ivo; Zaugg, Claudio; Kaufmann, Heiner; Both, Marcel; Vering, Thomas; Schaller, Helga C; Schaupp, Lukas; Bodenlenz, Manfred; Pieber, Thomas RThe objective of the project Advanced Insulin Infusion using a Control Loop ADICOL was to develop a treatment system that continuously measures and controls the glucose concentration in subjects with type 1 diabetes The modular concept of the ADICOL s extracorporeal artificial pancreas consisted of a minimally invasive subcutaneous glucose system a handheld PocketPC computer and an insulin pump D Tron Disetronic Burgdorf Switzerland delivering subcutaneously insulin lispro The present paper describes a subset of ADICOL activities focusing on the development of a glucose controller for semi closed loop control an in silico testing environment clinical testing and system integration An incremental approach was adopted to evaluate experimentally a model predictive glucose controller A feasibility study was followed by efficacy studies of increasing complexity The ADICOL project demonstrated feasibility of a semi closed loop glucose control during fasting and fed conditions with a wearable modular extracorporeal artificial pancreas