Browsing by Author "Bocchetta, Martina"
Now showing 1 - 10 of 10
Results Per Page
Sort Options
- ItemDelphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.(2014-08-18) Boccardi, Marina; Bocchetta, Martina; Apostolova, Liana G; Barnes, Josephine; Bartzokis, George; Corbetta, Gabriele; DeCarli, Charles; deToledo-Morrell, Leyla; Firbank, Michael; Ganzola, Rossana; Gerritsen, Lotte; Henneman, Wouter; Killiany, Ronald J; Malykhin, Nikolai; Pasqualetti, Patrizio; Pruessner, Jens C; Redolfi, Alberto; Robitaille, Nicolas; Soininen, Hilkka; Tolomeo, Daniele; Wang, Lei; Watson, Craig; Wolf, Henrike; Duvernoy, Henri; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B; ,This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures to define standard operating procedures for magnetic resonance MR based manual hippocampal segmentation
- ItemThe EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity.(2014-09-30) Frisoni, Giovanni B; Jack, Clifford R; Bocchetta, Martina; Bauer, Corinna; Frederiksen, Kristian S; Liu, Yawu; Preboske, Gregory; Swihart, Tim; Blair, Melanie; Cavedo, Enrica; Grothe, Michel J; Lanfredi, Mariangela; Martinez, Oliver; Nishikawa, Masami; Portegies, Marileen; Stoub, Travis; Ward, Chadwich; Apostolova, Liana G; Ganzola, Rossana; Wolf, Dominik; Barkhof, Frederik; Bartzokis, George; DeCarli, Charles; Csernansky, John G; deToledo-Morrell, Leyla; Geerlings, Mirjam I; Kaye, Jeffrey; Killiany, Ronald J; Lehéricy, Stephane; Matsuda, Hiroshi; O'Brien, John; Silbert, Lisa C; Scheltens, Philip; Soininen, Hilkka; Teipel, Stefan; Waldemar, Gunhild; Fellgiebel, Andreas; Barnes, Josephine; Firbank, Michael; Gerritsen, Lotte; Henneman, Wouter; Malykhin, Nikolai; Pruessner, Jens C; Wang, Lei; Watson, Craig; Wolf, Henrike; deLeon, Mony; Pantel, Johannes; Ferrari, Clarissa; Bosco, Paolo; Pasqualetti, Patrizio; Duchesne, Simon; Duvernoy, Henri; Boccardi, Marina; ,An international Delphi panel has defined a harmonized protocol HarP for the manual segmentation of the hippocampus on MR The aim of this study is to study the concurrent validity of the HarP toward local protocols and its major sources of variance
- ItemEstablishing magnetic resonance images orientation for the EADC-ADNI manual hippocampal segmentation protocol.(2014-09-08) Boccardi, Marina; Bocchetta, Martina; Apostolova, Liana G; Preboske, Gregory; Robitaille, Nicolas; Pasqualetti, Patrizio; Collins, Louis D; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B; ,An effort to define and validate a Harmonized Protocol for standard hippocampal segmentation is being carried out We wished to estimate the effect of magnetic resonance image MRI spatial orientation on manual hippocampal segmentations to define optimal standard orientation of MRIs for hippocampal volumetry
- ItemHarmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project.(2014-09-16) Bocchetta, Martina; Boccardi, Marina; Ganzola, Rossana; Apostolova, Liana G; Preboske, Gregory; Wolf, Dominik; Ferrari, Clarissa; Pasqualetti, Patrizio; Robitaille, Nicolas; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B; ,A globally harmonized protocol HarP for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer s Disease Consortium EADC and Alzheimer s Disease Neuroimaging Initiative ADNI Our aim was to produce benchmark labels based on the HarP for manual segmentation
- ItemManual segmentation qualification platform for the EADC-ADNI harmonized protocol for hippocampal segmentation project.(2015-01-24) Duchesne, Simon; Valdivia, Fernando; Robitaille, Nicolas; Mouiha, Abderazzak; Valdivia, F Abiel; Bocchetta, Martina; Apostolova, Liana G; Ganzola, Rossana; Preboske, Greg; Wolf, Dominik; Boccardi, Marina; Jack, Clifford R; Frisoni, Giovanni B; ,The use of hippocampal volumetry as a biomarker for Alzheimer s disease AD requires that tracers from different laboratories comply with the same segmentation method Here we present a platform for training and qualifying new tracers to perform the manual segmentation of the hippocampus on magnetic resonance images MRI following the European Alzheimer s Disease Consortium and Alzheimer s Disease Neuroimaging Initiative EADC ADNI Harmonized Protocol HarP Our objective was to demonstrate that the training process embedded in the platform leads to increased compliance and qualification with the HarP
- ItemMedial temporal atrophy in early and late-onset Alzheimer's disease.(2014-06-10) Cavedo, Enrica; Pievani, Michela; Boccardi, Marina; Galluzzi, Samantha; Bocchetta, Martina; Bonetti, Matteo; Thompson, Paul M; Frisoni, Giovanni BLate onset and early onset Alzheimer s disease LOAD EOAD affect different neural systems and may be separate nosographic entities The most striking differences are in the medial temporal lobe severely affected in LOAD and relatively spared in EOAD We assessed amygdalar morphology and volume in 18 LOAD and 18 EOAD patients and 36 aged matched controls and explored their relationship with the hippocampal volume Three dimensional amygdalar shape was reconstructed with the radial atrophy mapping technique hippocampal volume was measured using a manual method Atrophy was greater in LOAD than EOAD 25 versus 17 in the amygdala and 20 versus 13 in the hippocampus In the amygdala LOAD showed significantly greater tissue loss than EOAD in the right dorsal central lateral and basolateral nuclei 20 30 loss p Under 0 03 all known to be connected to limbic regions In LOAD but not EOAD greater hippocampal atrophy was associated with amygdalar atrophy in the left dorsal central and medial nuclei r 0 6 p Under 0 05 also part of the limbic system These findings support the notion that limbic involvement is a prominent feature of LOAD but not EOAD
- ItemQuantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: Towards a harmonized segmentation protocol.(2015-02-21) Yushkevich, Paul A; Amaral, Robert S C; Augustinack, Jean C; Bender, Andrew R; Bernstein, Jeffrey D; Boccardi, Marina; Bocchetta, Martina; Burggren, Alison C; Carr, Valerie A; Chakravarty, M Mallar; Chételat, Gael; Daugherty, Ana M; Davachi, Lila; Ding, Song-Lin; Ekstrom, Arne; Geerlings, Mirjam I; Hassan, Abdul; Huang, Yushan; Iglesias, J Eugenio; La Joie, Renaud; Kerchner, Geoffrey A; LaRocque, Karen F; Libby, Laura A; Malykhin, Nikolai; Mueller, Susanne G; Olsen, Rosanna K; Palombo, Daniela J; Parekh, Mansi B; Pluta, John B; Preston, Alison R; Pruessner, Jens C; Ranganath, Charan; Raz, Naftali; Schlichting, Margaret L; Schoemaker, Dorothee; Singh, Sachi; Stark, Craig E L; Suthana, Nanthia; Tompary, Alexa; Turowski, Marta M; Van Leemput, Koen; Wagner, Anthony D; Wang, Lei; Winterburn, Julie L; Wisse, Laura E M; Yassa, Michael A; Zeineh, Michael M; ,An increasing number of human in vivo magnetic resonance imaging MRI studies have focused on examining the structure and function of the subfields of the hippocampal formation the dentate gyrus CA fields 1 3 and the subiculum and subregions of the parahippocampal gyrus entorhinal perirhinal and parahippocampal cortices The ability to interpret the results of such studies and to relate them to each other would be improved if a common standard existed for labeling hippocampal subfields and parahippocampal subregions Currently research groups label different subsets of structures and use different rules landmarks and cues to define their anatomical extents This paper characterizes both qualitatively and quantitatively the variability in the existing manual segmentation protocols for labeling hippocampal and parahippocampal substructures in MRI with the goal of guiding subsequent work on developing a harmonized substructure segmentation protocol
- ItemRelationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol.(2015-01-26) Apostolova, Liana G; Zarow, Chris; Biado, Kristina; Hurtz, Sona; Boccardi, Marina; Somme, Johanne; Honarpisheh, Hedieh; Blanken, Anna E; Brook, Jenny; Tung, Spencer; Lo, Darrick; Ng, Denise; Alger, Jeffry R; Vinters, Harry V; Bocchetta, Martina; Duvernoy, Henri; Jack, Clifford R; Frisoni, Giovanni; ,The pathologic validation of European Alzheimer s Disease Consortium Alzheimer s Disease Neuroimaging Center Harmonized Hippocampal Segmentation Protocol HarP
- ItemTraining labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol.(2015-01-24) Boccardi, Marina; Bocchetta, Martina; Morency, Félix C; Collins, D Louis; Nishikawa, Masami; Ganzola, Rossana; Grothe, Michel J; Wolf, Dominik; Redolfi, Alberto; Pievani, Michela; Antelmi, Luigi; Fellgiebel, Andreas; Matsuda, Hiroshi; Teipel, Stefan; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B; ,The European Alzheimer s Disease Consortium and Alzheimer s Disease Neuroimaging Initiative ADNI Harmonized Protocol HarP is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging MRI that can be used as the standard of truth to train new tracers and to validate automated segmentation algorithms Training requires large and representative data sets of segmented hippocampi This work aims to produce a set of HarP labels for the proper training and certification of tracers and algorithms
- ItemThe use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey.(2014-08-24) Bocchetta, Martina; Galluzzi, Samantha; Kehoe, Patrick Gavin; Aguera, Eduardo; Bernabei, Roberto; Bullock, Roger; Ceccaldi, Mathieu; Dartigues, Jean-François; de Mendonça, Alexandre; Didic, Mira; Eriksdotter, Maria; Félician, Olivier; Frölich, Lutz; Gertz, Hermann-Josef; Hallikainen, Merja; Hasselbalch, Steen G; Hausner, Lucrezia; Heuser, Isabell; Jessen, Frank; Jones, Roy W; Kurz, Alexander; Lawlor, Brian; Lleo, Alberto; Martinez-Lage, Pablo; Mecocci, Patrizia; Mehrabian, Shima; Monsch, Andreas; Nobili, Flavio; Nordberg, Agneta; Olde Rikkert, Marcel; Orgogozo, Jean-Marc; Pasquier, Florence; Peters, Oliver; Salmon, Eric; Sánchez-Castellano, Carmen; Santana, Isabel; Sarazin, Marie; Traykov, Latchezar; Tsolaki, Magda; Visser, Pieter Jelle; Wallin, Asa K; Wilcock, Gordon; Wilkinson, David; Wolf, Henrike; Yener, Görsev; Zekry, Dina; Frisoni, Giovanni BWe investigated the use of Alzheimer s disease AD biomarkers in European Alzheimer s Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment MCI We surveyed availability frequency of use and confidence in diagnostic usefulness of markers of brain amyloidosis amyloid positron emission tomography PET cerebrospinal fluid CSF A 42 and neurodegeneration medial temporal atrophy MTA on MR fluorodeoxyglucose positron emission tomography FDG PET CSF tau The most frequently used biomarker is visually rated MTA 75 of the 37 responders reported using it always frequently followed by CSF markers 22 FDG PET 16 and amyloid PET 3 Only 45 of responders perceive MTA as contributing to diagnostic confidence where the contribution was rated as moderate Seventy nine percent of responders felt very extremely comfortable delivering a diagnosis of MCI due to AD when both amyloid and neuronal injury biomarkers were abnormal P Under 02 versus any individual biomarker Responders largely agreed that a combination of amyloidosis and neuronal injury biomarkers was a strongly indicative AD signature