Browsing by Author "Boccardi, Marina"
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- ItemCognitive rehabilitation for severe dementia: critical observations for better use of existing knowledge.(2006-02-06) Boccardi, Marina; Frisoni, Giovanni BCognitive rehabilitation for severely demented patients is a hard job for a number of reasons The most recent evidence based strategies such as the cued recall or the spaced retrieval techniques aim to improve cognitive function at initial stages of the disease while in more severe stages interventions such as validation therapy are used which are traditionally adopted but lack a solid scientific rationale and often even a consistent evidence based efficacy Many studies have been carried out to try demonstrate the effect of these therapies or to project new interventions while little attention has been given to the fact that simple neuropsychological principles keeping into account the nature of the pathological aging observed in dementia can be fruitfully adopted to improve and personalize different kinds of intervention A rational use of current neuropsychological concepts optimizes the patient s benefit as well as the operator s efforts A rehabilitative intervention based on current neuropsychological concepts and on awareness of the mechanisms of pathological ageing of cognition provides the possibility of tailored treatments for many different patients an important reduction of burn out in the personnel and clinically relevant outcomes such as an implicit orientation for the patient with beneficial effects on mood and behavior
- ItemDelphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.(2014-08-18) Boccardi, Marina; Bocchetta, Martina; Apostolova, Liana G; Barnes, Josephine; Bartzokis, George; Corbetta, Gabriele; DeCarli, Charles; deToledo-Morrell, Leyla; Firbank, Michael; Ganzola, Rossana; Gerritsen, Lotte; Henneman, Wouter; Killiany, Ronald J; Malykhin, Nikolai; Pasqualetti, Patrizio; Pruessner, Jens C; Redolfi, Alberto; Robitaille, Nicolas; Soininen, Hilkka; Tolomeo, Daniele; Wang, Lei; Watson, Craig; Wolf, Henrike; Duvernoy, Henri; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B; ,This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures to define standard operating procedures for magnetic resonance MR based manual hippocampal segmentation
- ItemThe EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity.(2014-09-30) Frisoni, Giovanni B; Jack, Clifford R; Bocchetta, Martina; Bauer, Corinna; Frederiksen, Kristian S; Liu, Yawu; Preboske, Gregory; Swihart, Tim; Blair, Melanie; Cavedo, Enrica; Grothe, Michel J; Lanfredi, Mariangela; Martinez, Oliver; Nishikawa, Masami; Portegies, Marileen; Stoub, Travis; Ward, Chadwich; Apostolova, Liana G; Ganzola, Rossana; Wolf, Dominik; Barkhof, Frederik; Bartzokis, George; DeCarli, Charles; Csernansky, John G; deToledo-Morrell, Leyla; Geerlings, Mirjam I; Kaye, Jeffrey; Killiany, Ronald J; Lehéricy, Stephane; Matsuda, Hiroshi; O'Brien, John; Silbert, Lisa C; Scheltens, Philip; Soininen, Hilkka; Teipel, Stefan; Waldemar, Gunhild; Fellgiebel, Andreas; Barnes, Josephine; Firbank, Michael; Gerritsen, Lotte; Henneman, Wouter; Malykhin, Nikolai; Pruessner, Jens C; Wang, Lei; Watson, Craig; Wolf, Henrike; deLeon, Mony; Pantel, Johannes; Ferrari, Clarissa; Bosco, Paolo; Pasqualetti, Patrizio; Duchesne, Simon; Duvernoy, Henri; Boccardi, Marina; ,An international Delphi panel has defined a harmonized protocol HarP for the manual segmentation of the hippocampus on MR The aim of this study is to study the concurrent validity of the HarP toward local protocols and its major sources of variance
- ItemEffect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter.(2008-03-24) Boccardi, Marina; Scassellati, Catia; Ghidoni, Roberta; Testa, Cristina; Benussi, Luisa; Bonetti, Matteo; Bocchio-Chiavetto, Luisella; Gennarelli, Massimo; Binetti, Giuliano; Frisoni, Giovanni BThe frequent polymorphism XbaI A351G in the estrogen receptor alpha ERalpha gene has been associated with some postmenopausal pathologies risk such as Alzheimer s disease AD or cognitive decline In the present study we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel based morphometry VBM on 20 magnetic resonance images of healthy postmenopausal women Subjects carrying the less common XbaI X allele were contrasted to non carriers in groups well balanced by relevant confounding variables The XbaI X allele carriers displayed clusters ranging from 9 to 28 of tissue reductions in the cerebellar cluster size z stereotactic coordinates 16 mm 3 3 17 14 94 38 and cerebral cortex in particular in the occipital lobe 272 mm 3 3 76 38 68 16 in the middle frontal gyrus 192 mm 3 3 71 38 12 38 and in the middle temporal gyrus while the opposite comparison was negative The XbaI X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex This allele might increase the susceptibility for senile neurodegenerative conditions being associated to smaller cerebral reserve
- ItemEffects of hormone therapy on brain morphology of healthy postmenopausal women: a Voxel-based morphometry study.(2006-08-09) Boccardi, Marina; Ghidoni, Roberta; Govoni, Stefano; Testa, Cristina; Benussi, Luisa; Bonetti, Matteo; Binetti, Giuliano; Frisoni, Giovanni BEstrogens are known to be protective in age associated cognitive changes in humans and in neurodegeneration in animal models The aim of this study was to evaluate the potential effects of estrogen therapy ET on human gray matter volume in vivo
- ItemEstablishing magnetic resonance images orientation for the EADC-ADNI manual hippocampal segmentation protocol.(2014-09-08) Boccardi, Marina; Bocchetta, Martina; Apostolova, Liana G; Preboske, Gregory; Robitaille, Nicolas; Pasqualetti, Patrizio; Collins, Louis D; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B; ,An effort to define and validate a Harmonized Protocol for standard hippocampal segmentation is being carried out We wished to estimate the effect of magnetic resonance image MRI spatial orientation on manual hippocampal segmentations to define optimal standard orientation of MRIs for hippocampal volumetry
- ItemHarmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project.(2014-09-16) Bocchetta, Martina; Boccardi, Marina; Ganzola, Rossana; Apostolova, Liana G; Preboske, Gregory; Wolf, Dominik; Ferrari, Clarissa; Pasqualetti, Patrizio; Robitaille, Nicolas; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B; ,A globally harmonized protocol HarP for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer s Disease Consortium EADC and Alzheimer s Disease Neuroimaging Initiative ADNI Our aim was to produce benchmark labels based on the HarP for manual segmentation
- ItemHippocampal and amygdalar local structural differences in elderly patients with schizophrenia.(2014-12-16) Prestia, Annapaola; Cavedo, Enrica; Boccardi, Marina; Muscio, Cristina; Adorni, Andrea; Geroldi, Cristina; Bonetti, Matteo; Thompson, Paul M; Frisoni, Giovanni BMorphological abnormalities have been reported for the hippocampi and amygdalae in young schizophrenia patients but very little is known about the pattern of abnormalities in elderly schizophrenia patients Here we investigated local structural differences in the hippocampi and amygdalae of elderly schizophrenia patients compared with healthy elderly subjects We also related these differences to clinical symptom severity
- ItemHippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia.(2011-05-02) Prestia, Annapaola; Boccardi, Marina; Galluzzi, Samantha; Cavedo, Enrica; Adorni, Andrea; Soricelli, Andrea; Bonetti, Matteo; Geroldi, Cristina; Giannakopoulos, Panteleimon; Thompson, Paul; Frisoni, GiovanniPatients with Alzheimer s disease AD and schizophrenia display cognitive behavioural disturbances and morphological abnormalities Although these latter reflect progressive neurodegeneration in AD their significance in schizophrenia is still unclear We explored the patterns of hippocampal and amygdalar atrophy in those patients and their associations with clinical parameters Structural magnetic resonance imaging was performed in 20 elderly schizophrenia patients 20 AD and 19 healthy older controls Hippocampal and amygdalar volumes were obtained by manual segmentation with a standardized protocol and compared among groups In both schizophrenia and AD patients left hippocampal and amygdalar volumes were significantly smaller The hippocampus amygdala ratio was significantly lower in schizophrenia compared to both AD cases 2 4 bilaterally 95 C I 2 2 to 2 7 and healthy controls bilaterally 2 5 95 C I 2 3 to 2 9 in left and 2 7 95 C I 2 4 to 3 1 in right hemisphere In schizophrenia patients a significant positive correlation was found between age at disease onset and the right hippocampus amygdala volume ratio Spearman rho 0 56 Negative symptoms correlated with higher right left amygdala volume ratio Spearman s rho 0 43 Our data show that unlike AD the hippocampus amygdala ratio is abnormally low and correlates with the age at onset in schizophrenia being a neurodevelopmental signature of the disease
- ItemInfluence of serotonin receptor 2A His452Tyr polymorphism on brain temporal structures: a volumetric MR study.(2006-03-23) Filippini, Nicola; Scassellati, Catia; Boccardi, Marina; Pievani, Michela; Testa, Cristina; Bocchio-Chiavetto, Luisella; Frisoni, Giovanni B; Gennarelli, MassimoSerotonin 5 HT receptors 2A are expressed in brain regions involved in memory and learning processes Recently a functional single nucleotide polymorphism in the 5 HT2A receptor gene leading to an amino acid substitution at residue 452 His452Tyr has been involved in memory performance persons with the rare 452Tyr allele showing poorer memory performance compared to His452His subjects To investigate a putative structural effect of this polymorphism on temporal areas typically involved in memory processes we performed voxel based morphometry VBM and region of interest ROI volumetric analysis on high resolution magnetic resonance images in 15 carriers and 61 noncarriers of the 452Tyr allele ROI volumetric analysis showed a significant reduction of the fractional volume of the temporal white matter in 452Tyr carriers 0 67 0 07 vs 0 73 0 08 P 0 007 VBM confirmed this finding and in addition showed reduced grey matter in the left hippocampus left inferior temporal gyrus and bilaterally in the middle and superior temporal gyrus A possible effect on synaptic plasticity or neurodevelopment might explain the influence of the His452Tyr polymorphism on temporal brain structures and this might be the basis for poorer memory performance in 452Tyr carriers These findings should be considered preliminary and future replication is needed
- ItemManual segmentation qualification platform for the EADC-ADNI harmonized protocol for hippocampal segmentation project.(2015-01-24) Duchesne, Simon; Valdivia, Fernando; Robitaille, Nicolas; Mouiha, Abderazzak; Valdivia, F Abiel; Bocchetta, Martina; Apostolova, Liana G; Ganzola, Rossana; Preboske, Greg; Wolf, Dominik; Boccardi, Marina; Jack, Clifford R; Frisoni, Giovanni B; ,The use of hippocampal volumetry as a biomarker for Alzheimer s disease AD requires that tracers from different laboratories comply with the same segmentation method Here we present a platform for training and qualifying new tracers to perform the manual segmentation of the hippocampus on magnetic resonance images MRI following the European Alzheimer s Disease Consortium and Alzheimer s Disease Neuroimaging Initiative EADC ADNI Harmonized Protocol HarP Our objective was to demonstrate that the training process embedded in the platform leads to increased compliance and qualification with the HarP
- ItemMedial temporal atrophy in early and late-onset Alzheimer's disease.(2014-06-10) Cavedo, Enrica; Pievani, Michela; Boccardi, Marina; Galluzzi, Samantha; Bocchetta, Martina; Bonetti, Matteo; Thompson, Paul M; Frisoni, Giovanni BLate onset and early onset Alzheimer s disease LOAD EOAD affect different neural systems and may be separate nosographic entities The most striking differences are in the medial temporal lobe severely affected in LOAD and relatively spared in EOAD We assessed amygdalar morphology and volume in 18 LOAD and 18 EOAD patients and 36 aged matched controls and explored their relationship with the hippocampal volume Three dimensional amygdalar shape was reconstructed with the radial atrophy mapping technique hippocampal volume was measured using a manual method Atrophy was greater in LOAD than EOAD 25 versus 17 in the amygdala and 20 versus 13 in the hippocampus In the amygdala LOAD showed significantly greater tissue loss than EOAD in the right dorsal central lateral and basolateral nuclei 20 30 loss p Under 0 03 all known to be connected to limbic regions In LOAD but not EOAD greater hippocampal atrophy was associated with amygdalar atrophy in the left dorsal central and medial nuclei r 0 6 p Under 0 05 also part of the limbic system These findings support the notion that limbic involvement is a prominent feature of LOAD but not EOAD
- ItemOccipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease.(2015-02-03) Babiloni, Claudio; Del Percio, Claudio; Boccardi, Marina; Lizio, Roberta; Lopez, Susanna; Carducci, Filippo; Marzano, Nicola; Soricelli, Andrea; Ferri, Raffaele; Triggiani, Antonio Ivano; Prestia, Annapaola; Salinari, Serenella; Rasser, Paul E; Basar, Erol; Famà, Francesco; Nobili, Flavio; Yener, Görsev; Emek-Savaş, Derya Durusu; Gesualdo, Loreto; Mundi, Ciro; Thompson, Paul M; Rossini, Paolo M; Frisoni, Giovanni BOccipital sources of resting state electroencephalographic EEG alpha rhythms are abnormal at the group level in patients with amnesic mild cognitive impairment MCI and Alzheimer s disease AD Here we evaluated the hypothesis that amplitude of these occipital sources is related to neurodegeneration in occipital lobe as measured by magnetic resonance imaging Resting state eyes closed EEG rhythms were recorded in 45 healthy elderly Nold 100 MCI and 90 AD subjects Neurodegeneration of occipital lobe was indexed by weighted averages of gray matter density estimated from structural MRIs EEG rhythms of interest were alpha 1 8 10 5 Hz and alpha 2 10 5 13 Hz EEG cortical sources were estimated by low resolution brain electromagnetic tomography Results showed a positive correlation between occipital gray matter density and amplitude of occipital alpha 1 sources in Nold MCI and AD subjects as a whole group r 0 3 p 0 000004 N 235 Furthermore there was a positive correlation between the amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Examination score across all subjects r 0 38 p 0 000001 N 235 Finally amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects sensitivity 87 8 specificity 66 7 area under the receiver operating characteristic curve 0 81 These results suggest that the amplitude of occipital sources of resting state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging
- ItemQuantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: Towards a harmonized segmentation protocol.(2015-02-21) Yushkevich, Paul A; Amaral, Robert S C; Augustinack, Jean C; Bender, Andrew R; Bernstein, Jeffrey D; Boccardi, Marina; Bocchetta, Martina; Burggren, Alison C; Carr, Valerie A; Chakravarty, M Mallar; Chételat, Gael; Daugherty, Ana M; Davachi, Lila; Ding, Song-Lin; Ekstrom, Arne; Geerlings, Mirjam I; Hassan, Abdul; Huang, Yushan; Iglesias, J Eugenio; La Joie, Renaud; Kerchner, Geoffrey A; LaRocque, Karen F; Libby, Laura A; Malykhin, Nikolai; Mueller, Susanne G; Olsen, Rosanna K; Palombo, Daniela J; Parekh, Mansi B; Pluta, John B; Preston, Alison R; Pruessner, Jens C; Ranganath, Charan; Raz, Naftali; Schlichting, Margaret L; Schoemaker, Dorothee; Singh, Sachi; Stark, Craig E L; Suthana, Nanthia; Tompary, Alexa; Turowski, Marta M; Van Leemput, Koen; Wagner, Anthony D; Wang, Lei; Winterburn, Julie L; Wisse, Laura E M; Yassa, Michael A; Zeineh, Michael M; ,An increasing number of human in vivo magnetic resonance imaging MRI studies have focused on examining the structure and function of the subfields of the hippocampal formation the dentate gyrus CA fields 1 3 and the subiculum and subregions of the parahippocampal gyrus entorhinal perirhinal and parahippocampal cortices The ability to interpret the results of such studies and to relate them to each other would be improved if a common standard existed for labeling hippocampal subfields and parahippocampal subregions Currently research groups label different subsets of structures and use different rules landmarks and cues to define their anatomical extents This paper characterizes both qualitatively and quantitatively the variability in the existing manual segmentation protocols for labeling hippocampal and parahippocampal substructures in MRI with the goal of guiding subsequent work on developing a harmonized substructure segmentation protocol
- ItemRelationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol.(2015-01-26) Apostolova, Liana G; Zarow, Chris; Biado, Kristina; Hurtz, Sona; Boccardi, Marina; Somme, Johanne; Honarpisheh, Hedieh; Blanken, Anna E; Brook, Jenny; Tung, Spencer; Lo, Darrick; Ng, Denise; Alger, Jeffry R; Vinters, Harry V; Bocchetta, Martina; Duvernoy, Henri; Jack, Clifford R; Frisoni, Giovanni; ,The pathologic validation of European Alzheimer s Disease Consortium Alzheimer s Disease Neuroimaging Center Harmonized Hippocampal Segmentation Protocol HarP
- ItemTraining labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol.(2015-01-24) Boccardi, Marina; Bocchetta, Martina; Morency, Félix C; Collins, D Louis; Nishikawa, Masami; Ganzola, Rossana; Grothe, Michel J; Wolf, Dominik; Redolfi, Alberto; Pievani, Michela; Antelmi, Luigi; Fellgiebel, Andreas; Matsuda, Hiroshi; Teipel, Stefan; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B; ,The European Alzheimer s Disease Consortium and Alzheimer s Disease Neuroimaging Initiative ADNI Harmonized Protocol HarP is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging MRI that can be used as the standard of truth to train new tracers and to validate automated segmentation algorithms Training requires large and representative data sets of segmented hippocampi This work aims to produce a set of HarP labels for the proper training and certification of tracers and algorithms