Case-control study of the association between malignant brain tumours diagnosed between 2007 and 2009 and mobile and cordless phone use.

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2013-10-22
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Previous studies have shown a consistent association between long term use of mobile and cordless phones and glioma and acoustic neuroma but not for meningioma When used these phones emit radiofrequency electromagnetic fields RF EMFs and the brain is the main target organ for the handheld phone The International Agency for Research on Cancer IARC classified in May 2011 RF EMF as a group 2B i e a possible human carcinogen The aim of this study was to further explore the relationship between especially long term 10 years use of wireless phones and the development of malignant brain tumours We conducted a new case control study of brain tumour cases of both genders aged 18 75 years and diagnosed during 2007 2009 One population based control matched on gender and age within 5 years was used to each case Here we report on malignant cases including all available controls Exposures on e g use of mobile phones and cordless phones were assessed by a self administered questionnaire Unconditional logistic regression analysis was performed adjusting for age gender year of diagnosis and socio economic index using the whole control sample Of the cases with a malignant brain tumour 87 n 593 participated and 85 n 1 368 of controls in the whole study answered the questionnaire The odds ratio OR for mobile phone use of the analogue type was 1 8 95 confidence interval CI 1 04 3 3 increasing with 25 years of latency time since first exposure to an OR 3 3 95 CI 1 6 6 9 Digital 2G mobile phone use rendered an OR 1 6 95 CI 0 996 2 7 increasing with latency 15 20 years to an OR 2 1 95 CI 1 2 3 6 The results for cordless phone use were OR 1 7 95 CI 1 1 2 9 and for latency of 15 20 years the OR 2 1 95 CI 1 2 3 8 Few participants had used a cordless phone for 20 25 years Digital type of wireless phones 2G and 3G mobile phones cordless phones gave increased risk with latency 1 5 years then a lower risk in the following latency groups but again increasing risk with latency 15 20 years Ipsilateral use resulted in a higher risk than contralateral mobile and cordless phone use Higher ORs were calculated for tumours in the temporal and overlapping lobes Using the meningioma cases in the same study as reference entity gave somewhat higher ORs indicating that the results were unlikely to be explained by recall or observational bias This study confirmed previous results of an association between mobile and cordless phone use and malignant brain tumours These findings provide support for the hypothesis that RF EMFs play a role both in the initiation and promotion stages of carcinogenesis
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