MEASURE Evaluation developed a set of 30 indicators to assess the status of health information systems (HIS) at country level. This collection includes the list of indicators and an analysis of the status of HIS in 39 United States Agency for International Development (USAID) priority countries. The results are presented for (1) all countries, (2) for United States President’s Emergency Plan for AIDS Relief (PEPFAR) countries, and (3) for focus countries where USAID is working to achieve the goal of preventing child and maternal deaths. The individual profile for each country can be accessed at https://www.measureevaluation.org/his-strengthening-resource-center/country-profiles.