Pooled analysis of case-control studies on acoustic neuroma diagnosed 1997-2003 and 2007-2009 and use of mobile and cordless phones.

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2013-08-14
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We previously conducted a case control study of acoustic neuroma Subjects of both genders aged 20 80 years diagnosed during 1997 2003 in parts of Sweden were included and the results were published We have since made a further study for the time period 2007 2009 including both men and women aged 18 75 years selected from throughout the country These new results for acoustic neuroma have not been published to date Similar methods were used for both study periods In each one population based control matched on gender and age within five years was identified from the Swedish Population Registry Exposures were assessed by a self administered questionnaire supplemented by a phone interview Since the number of acoustic neuroma cases in the new study was low we now present pooled results from both study periods based on 316 participating cases and 3 530 controls Unconditional logistic regression analysis was performed adjusting for age gender year of diagnosis and socio economic index SEI Use of mobile phones of the analogue type gave odds ratio OR 2 9 95 confidence interval CI 2 0 4 3 increasing with 20 years latency time since first exposure to OR 7 7 95 CI 2 8 21 Digital 2G mobile phone use gave OR 1 5 95 CI 1 1 2 1 increasing with latency 15 years to an OR 1 8 95 CI 0 8 4 2 The results for cordless phone use were OR 1 5 95 CI 1 1 2 1 and for latency of 20 years OR 6 5 95 CI 1 7 26 Digital type wireless phones 2G and 3G mobile phones and cordless phones gave OR 1 5 95 CI 1 1 2 0 increasing to OR 8 1 95 CI 2 0 32 with latency 20 years For total wireless phone use the highest risk was calculated for the longest latency time 20 years OR 4 4 95 CI 2 2 9 0 Several of the calculations in the long latency category were based on low numbers of exposed cases Ipsilateral use resulted in a higher risk than contralateral for both mobile and cordless phones OR increased per 100 h cumulative use and per year of latency for mobile phones and cordless phones though the increase was not statistically significant for cordless phones The percentage tumour volume increased per year of latency and per 100 h of cumulative use statistically significant for analogue phones This study confirmed previous results demonstrating an association between mobile and cordless phone use and acoustic neuroma
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