The in vivo topography of cortical changes in healthy aging and prodromal Alzheimer's disease.
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Date
2013-09-23
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Abstract
Gray matter atrophy is regarded as a valid marker of neurodegeneration in Alzheimer s disease AD but few studies have investigated in detail the topographic changes associated with normal aging In addition few studies have compared the changes in the earliest clinical stage of AD prodromal AD pAD with those of healthy aging Here we aimed to investigate the topographical distribution of age related cortical atrophy and to compare it with that associated with prodromal and estabilished AD