Now showing items 1-10 of 38
Decision tool for the early diagnosis of trauma patient hypovolemia.
We present a classifier for use as a decision assist tool to identify a hypovolemic state in trauma patients during helicopter transport to a hospital when reliable acquisition of vital sign data may be difficult The ...
Evidence of probabilistic behaviour in protein interaction networks.
Data from high throughput experiments of protein protein interactions are commonly used to probe the nature of biological organization and extract functional relationships between sets of proteins What has not been appreciated ...
Oligonucleotide fingerprint identification for microarray-based pathogen diagnostic assays.
Advances in DNA microarray technology and computational methods have unlocked new opportunities to identify DNA fingerprints i e oligonucleotide sequences that uniquely identify a specific genome We present an integrated ...
DOVIS: an implementation for high-throughput virtual screening using AutoDock.
Molecular docking based virtual screening is an important tool in drug discovery that is used to significantly reduce the number of possible chemical compounds to be investigated In addition to the selection of a sound ...
Moving towards individualized performance models.
Individualized short-term core temperature prediction in humans using biomathematical models.
This study compares and contrasts the ability of three different mathematical modeling techniques to predict individual specific body core temperature variations during physical activity The techniques include a first ...
Providing statistical measures of reliability for body core temperature predictions.
This paper describes the use of a data driven autoregressive integrated moving average model to predict body core temperature in humans during physical activity We also propose a bootstrap technique to provide a measure ...
Is heart rate variability better than routine vital signs for prehospital identification of major hemorrhage?
During initial assessment of trauma patients metrics of heart rate variability HRV have been associated with high risk clinical conditions Yet despite numerous studies the potential of HRV to improve clinical outcomes ...
A high-throughput pipeline for designing microarray-based pathogen diagnostic assays.
We present a methodology for high throughput design of oligonucleotide fingerprints for microarray based pathogen diagnostic assays The oligonucleotide fingerprints or DNA microarray probes are designed for identifying ...
Exploiting large-scale drug-protein interaction information for computational drug repurposing.
Despite increased investment in pharmaceutical research and development fewer and fewer new drugs are entering the marketplace This has prompted studies in repurposing existing drugs for use against diseases with unmet ...