Now showing items 1-10 of 37
The effect of white matter lesions on cognition in the elderly--small but detectable.
The extent to which white matter changes affect brain function in elderly individuals is a matter for debate Although there is a consensus that large confluent white matter lesions WMLs can be attributed to small vessel ...
Manual segmentation qualification platform for the EADC-ADNI harmonized protocol for hippocampal segmentation project.
The use of hippocampal volumetry as a biomarker for Alzheimer s disease AD requires that tracers from different laboratories comply with the same segmentation method Here we present a platform for training and qualifying ...
Training labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol.
The European Alzheimer s Disease Consortium and Alzheimer s Disease Neuroimaging Initiative ADNI Harmonized Protocol HarP is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging MRI that ...
Cognitive rehabilitation for severe dementia: critical observations for better use of existing knowledge.
Cognitive rehabilitation for severely demented patients is a hard job for a number of reasons The most recent evidence based strategies such as the cued recall or the spaced retrieval techniques aim to improve cognitive ...
White matter lesions in the elderly: pathophysiological hypothesis on the effect on brain plasticity and reserve.
The effect of white matter lesions WMLs on the brain of elderly individuals is unclear Most debate has focused on the clinical effect of WMLs on cognitive impairment Large cross sectional and longitudinal clinic and ...
Prescription patterns and efficacy of drugs for patients with dementia: physicians' perspective in Italy.
The aim of this study was to assess the prescription practices and judgment of efficacy of physicians of drugs used for the cognitive and non cognitive symptoms of dementia
Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele.
Functional magnetic resonance imaging MRI studies have shown that APOE 2 and 4 carriers have similar patterns of blood oxygenation level dependent BOLD activation suggesting that we need to look beyond the BOLD signal to ...
Establishing magnetic resonance images orientation for the EADC-ADNI manual hippocampal segmentation protocol.
An effort to define and validate a Harmonized Protocol for standard hippocampal segmentation is being carried out We wished to estimate the effect of magnetic resonance image MRI spatial orientation on manual hippocampal ...
Imaging as a biomarker in drug discovery for Alzheimer's disease: is MRI a suitable technology?
This review provides perspectives on the utility of magnetic resonance imaging MRI as a neuroimaging approach in the development of novel treatments for Alzheimer s disease These considerations were generated in a roundtable ...
The in vivo topography of cortical changes in healthy aging and prodromal Alzheimer's disease.
Gray matter atrophy is regarded as a valid marker of neurodegeneration in Alzheimer s disease AD but few studies have investigated in detail the topographic changes associated with normal aging In addition few studies have ...